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Mucinous adenocarcinoma of the ovary (view source)
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# | '''Mucinous adenocarcinoma of the ovary''' is a [[malignant]] [[ovarian tumour]]. | ||
It is also known as '''ovarian mucinous adenocarcinoma''' and '''ovarian mucinous carcinoma'''. | |||
==General== | |||
*Malignant. | |||
*May arise in [[endometriosis]].<ref name=Ref_PBoD1097>{{Ref PBoD |1097}}</ref> | |||
*Poor response to chemotherapy vis-à-vis serous carcinoma.<ref name=pmid19275957>{{Cite journal | last1 = Shimada | first1 = M. | last2 = Kigawa | first2 = J. | last3 = Ohishi | first3 = Y. | last4 = Yasuda | first4 = M. | last5 = Suzuki | first5 = M. | last6 = Hiura | first6 = M. | last7 = Nishimura | first7 = R. | last8 = Tabata | first8 = T. | last9 = Sugiyama | first9 = T. | title = Clinicopathological characteristics of mucinous adenocarcinoma of the ovary. | journal = Gynecol Oncol | volume = 113 | issue = 3 | pages = 331-4 | month = Jun | year = 2009 | doi = 10.1016/j.ygyno.2009.02.010 | PMID = 19275957 }}</ref> | |||
==Gross== | |||
Features: | |||
*Multiloculated. | |||
*Sticky, gelatinous fluid (glycoprotein). | |||
*+/-[[Necrosis]]. | |||
*Typically unilateral.<ref name=pmid22885379>{{Cite journal | last1 = Offman | first1 = SL. | last2 = Longacre | first2 = TA. | title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). | journal = Adv Anat Pathol | volume = 19 | issue = 5 | pages = 296-312 | month = Sep | year = 2012 | doi = 10.1097/PAP.0b013e31826663b1 | PMID = 22885379 }}</ref> | |||
==Microscopic== | |||
Features: | |||
*Mucinous differentiation. | |||
**Tall [[columnar cell]]s in glands with apical mucin. | |||
***May have an endocervical-like ''or'' intestinal-like appearance - see ''subtypes''. | |||
*Invasive morphology - one of the following: | |||
*#Back-to-back glands/confluent growth pattern. | |||
*#Desmoplastic stromal response. | |||
*#Cribriforming of glands. | |||
*Malignant characteristics: | |||
**+/-Nuclear atypia. | |||
**+/-Necrosis. | |||
**No cilia. | |||
DDx: | |||
*[[Mucinous borderline tumour of the ovary]]. | |||
*[[Metastatic]] [[mucinous carcinoma]]. | |||
===Subtypes=== | |||
#''Endocervical type''. | |||
#*Less likely to be malignant. | |||
#*More common than malignant type. | |||
#''Intestinal type''. | |||
#*More likely to be malignant. | |||
#*+/-[[Goblet cell]]s. | |||
#**One large clear apical vacuole. | |||
#*If it doesn't look like intestine to you... it probably isn't. | |||
#*May vaguely resemble colorectal adenocarcinoma (hyperchromatic, columnar nuclei, nuclear pleomorphism). | |||
#**Image: [http://www.ispub.com/xml/journals/ijgo/vol9n1/papillary-fig4.jpg] | |||
Comparison of mucosa: | |||
*Normal endocervical mucosa: [http://pathology.mc.duke.edu/research/Histo_course/endocx.jpg endocervical mucosa (duke.edu)]. | |||
*Normal colonic mucosa: [http://commons.wikimedia.org/wiki/File:Rectal_prolapse_-_intermed_mag.jpg colonic type mucosa (WC)]. | |||
==IHC== | |||
*CK7 +ve. | |||
*[[CK20]] +ve. | |||
==See also== | |||
*[[Ovarian tumours]]. | |||
*[[Mucinous adenocarcinoma]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Ovarian tumours]] | |||