Difference between revisions of "Ovarian tumours"

Ovarian tumours (view source)

1,138 bytes removed , 05:32, 2 May 2015

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 **Should '''not''' be confused with ''[[granular cell tumour]]''.
 **Ideally, it should be called ''adult granulosa cell tumour'' to avoid confusion with ''[[juvenile granulosa cell tumour]]''.
 {{Main| Adult granulosa cell tumour}}
-===Gross===
-*Classically solid.
-===IHC===
-* Inhibin positive.<ref name=Ref_PBoD1102>{{Ref PBoD|1102}}</ref>
-** Inhibin negative in ''[[Brenner tumour]]''.
-*Calretinin +ve.
-===Molecular===
-:Currently not used for diagnosis.
-*FOXL2 point mutation<ref name=pmid22240241 >{{Cite journal  | last1 = Jamieson | first1 = S. | last2 = Fuller | first2 = PJ. | title = Molecular pathogenesis of granulosa cell tumors of the ovary. | journal = Endocr Rev | volume = 33 | issue = 1 | pages = 109-44 | month = Feb | year = 2012 | doi = 10.1210/er.2011-0014 | PMID = 22240241 }}</ref> seen in 86 of 89 tumours.<ref name=pmid19516027>{{Cite journal  | last1 = Shah | first1 = SP. | last2 = Köbel | first2 = M. | last3 = Senz | first3 = J. | last4 = Morin | first4 = RD. | last5 = Clarke | first5 = BA. | last6 = Wiegand | first6 = KC. | last7 = Leung | first7 = G. | last8 = Zayed | first8 = A. | last9 = Mehl | first9 = E. | title = Mutation of FOXL2 in granulosa-cell tumors of the ovary. | journal = N Engl J Med | volume = 360 | issue = 26 | pages = 2719-29 | month = Jun | year = 2009 | doi = 10.1056/NEJMoa0902542 | PMID = 19516027 }}</ref>
 ==Fibroma-thecoma group==