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Difference between revisions of "Choroid plexus papilloma"
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| Caption = Choroid plexus papilloma [[H&E stain]]. | | Caption = Choroid plexus papilloma [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = papillary epithelial structures with bland cytology, mitoses uncommon | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = metastatic papillary [[adenocarcinoma]], [[ELST]] | | LMDDx = metastatic papillary [[adenocarcinoma]], [[ELST]] | ||
| Stains = | | Stains = | ||
| IHC = Kir 7.1+ve, EAAT1+ve, GFAP+/-, S-100+/-, CK+/- | | IHC = Kir 7.1 +ve, EAAT1 +ve, GFAP +ve/-ve, S-100 +ve/-ve, CK +ve/-ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 15: | Line 15: | ||
| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = all ventricles, cerebellopontine angle | | Site = all ventricles, [[cerebellopontine angle]] - see ''[[brain tumours]]'' | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = children | ||
| Signs = | | Signs = | ||
| Symptoms = hydrocephalus | | Symptoms = hydrocephalus | ||
| Prevalence = | | Prevalence = | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
| Line 30: | Line 30: | ||
| Tx = | | Tx = | ||
}} | }} | ||
'''Choroid plexus papilloma''', abbreviated '''CPP''', is a benign [[neuropathology]] arising in the ventricles of the brain. | |||
'''Choroid plexus papilloma''' is a benign [[neuropathology]] arising in the ventricles of the brain. | |||
==General== | ==General== | ||
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**WHO grade I (ICD-O: 9390/1). | **WHO grade I (ICD-O: 9390/1). | ||
**WHO grade II - atypical choroid plexus papilloma (ICD-O: 9390/1). | **WHO grade II - atypical choroid plexus papilloma (ICD-O: 9390/1). | ||
* Less than 1% of all brain | * Less than 1% of all [[brain tumours]]. | ||
** | ** Approximately 10-20% of all tumours in the first year of life. | ||
** Congenital | ** Congenital tumours reported. | ||
* | *Usually laternal ventricle in children.<ref>URL: [http://emedicine.medscape.com/article/250795-overview http://emedicine.medscape.com/article/250795-overview]. Accessed on: 3 June 2011.</ref> | ||
==Gross== | ==Gross== | ||
| Line 51: | Line 50: | ||
* 5% third ventricle. | * 5% third ventricle. | ||
* 40% fourth ventricle. | * 40% fourth ventricle. | ||
* 5% multiple | * 5% multiple tumours or cerebellopontine angle. | ||
==Microscopic== | ==Microscopic== | ||
| Line 60: | Line 59: | ||
*Rarely [[oncocytoma|oncocytic]] changes, mucinous degeneration. | *Rarely [[oncocytoma|oncocytic]] changes, mucinous degeneration. | ||
*[[Necrosis]] and brain invasion is uncommon. | *[[Necrosis]] and brain invasion is uncommon. | ||
* Atypical CPP: 2 or more mitoses /10 HPF.<ref>{{Cite journal | last1 = Wrede | first1 = B. | last2 = Hasselblatt | first2 = M. | last3 = Peters | first3 = O. | last4 = Thall | first4 = PF. | last5 = Kutluk | first5 = T. | last6 = Moghrabi | first6 = A. | last7 = Mahajan | first7 = A. | last8 = Rutkowski | first8 = S. | last9 = Diez | first9 = B. | title = Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. | journal = J Neurooncol | volume = 95 | issue = 3 | pages = 383-92 | month = Dec | year = 2009 | doi = 10.1007/s11060-009-9936-y | PMID = 19543851 }}</ref> | * Atypical CPP: 2 or more mitoses /10 HPF.<ref name=pmid19543851>{{Cite journal | last1 = Wrede | first1 = B. | last2 = Hasselblatt | first2 = M. | last3 = Peters | first3 = O. | last4 = Thall | first4 = PF. | last5 = Kutluk | first5 = T. | last6 = Moghrabi | first6 = A. | last7 = Mahajan | first7 = A. | last8 = Rutkowski | first8 = S. | last9 = Diez | first9 = B. | title = Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. | journal = J Neurooncol | volume = 95 | issue = 3 | pages = 383-92 | month = Dec | year = 2009 | doi = 10.1007/s11060-009-9936-y | PMID = 19543851 }}</ref> | ||
==IHC== | ==IHC== | ||