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Adenocarcinoma of the urinary bladder (view source)
Revision as of 21:02, 30 April 2015
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Image: Adenocarcinoma of the urinary bladder - beta-catenin -- very high mag.jpg | AUB - beta-catenin - very high mag. (WC) | Image: Adenocarcinoma of the urinary bladder - beta-catenin -- very high mag.jpg | AUB - beta-catenin - very high mag. (WC) | ||
</gallery> | </gallery> | ||
==Sign out== | |||
<pre> | |||
Urinary Bladder Tumour, Transurethral Resection: | |||
- Invasive adenocarcinoma into the lamina propria, see comment. | |||
- Muscularis propria not sampled. | |||
- Negative for lymphovascular invasion. | |||
Comment: | |||
No urothelial carcinoma component is identified. | |||
The differential diagnosis includes (1) primary adenocarcinoma of the | |||
bladder, (2) adenocarcinoma from another organ (direct extension or | |||
metastasis), (3) urothelial carcinoma with glandular differentiation | |||
without sampled urothelial carcinoma, and (4) urachal adenocarcinoma. | |||
Immunostaining of the tumour is as follows: | |||
POSITIVE: CK7, CK20, CK34betaE12. | |||
NEGATIVE: beta-catenin (membranous pattern only, nuclei are negative). | |||
The immunoprofile (beta-catenin = nuclei negative, CK7 = positive) and | |||
presence of an in situ component favours a primary adenocarcinoma of | |||
the bladder; however, this is uncommon. Nonprimary adenocarcinoma | |||
(e.g. colorectal adenocarcinoma) should be excluded clinically. | |||
</pre> | |||
==See also== | ==See also== | ||