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Difference between revisions of "Choroid plexus papilloma"
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| Signs = | | Signs = | ||
| Symptoms = hydrocephalus | | Symptoms = hydrocephalus | ||
| Prevalence = | | Prevalence = Children | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
| Line 34: | Line 34: | ||
==General== | ==General== | ||
Features: <ref name=Ref_WHOCNS_82>{{Ref WHOCNS|82}}</ref> | |||
*Low grade | |||
**WHO grade I (ICD-O: 9390/1). | |||
**WHO grade II - atypical choroid plexus papilloma (ICD-O: 9390/1). | |||
* Less than 1% of all brain tumors. | |||
** Approx. 10-20% of all tumors in the first year of life. | |||
** Congenital tumors reported. | |||
*Usu. laternal ventricle in kids.<ref>URL: [http://emedicine.medscape.com/article/250795-overview http://emedicine.medscape.com/article/250795-overview]. Accessed on: 3 June 2011.</ref> | *Usu. laternal ventricle in kids.<ref>URL: [http://emedicine.medscape.com/article/250795-overview http://emedicine.medscape.com/article/250795-overview]. Accessed on: 3 June 2011.</ref> | ||
==Gross== | |||
Features: <ref name=Ref_WHOCNS_82>{{Ref WHOCNS|82}}</ref> | |||
* Adhere to ventricular walls. | |||
* Circumscribed. | |||
* Villous architecture. | |||
* 50% lateral ventricles. | |||
* 5% third ventricle. | |||
* 40% fourth ventricle. | |||
* 5% multiple tumors or cerebellopontine angle. | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features: <ref name=pmid20644273>{{Cite journal | last1 = Menon | first1 = G. | last2 = Nair | first2 = SN. | last3 = Baldawa | first3 = SS. | last4 = Rao | first4 = RB. | last5 = Krishnakumar | first5 = KP. | last6 = Gopalakrishnan | first6 = CV. | title = Choroid plexus tumors: an institutional series of 25 patients. | journal = Neurol India | volume = 58 | issue = 3 | pages = 429-35 | month = | year = | doi = 10.4103/0028-3886.66455 | PMID = 20644273 |URL = http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2010;volume=58;issue=3;spage=429;epage=435;aulast=Menon }}</ref> | ||
*Simple epithelium. | *Simple epithelium. | ||
*Papillae. | *Papillae. | ||
*[[Psammoma body|Psammoma bodies]]. | *[[Psammoma body|Psammoma bodies]]. | ||
*Rarely [[oncocytoma|oncocytic]] changes, mucinous degeneration. | |||
*[[Necrosis]] and brain invasion is uncommon. | |||
* Atypical CPP: 2 or more mitoses /10 HPF.<ref>{{Cite journal | last1 = Wrede | first1 = B. | last2 = Hasselblatt | first2 = M. | last3 = Peters | first3 = O. | last4 = Thall | first4 = PF. | last5 = Kutluk | first5 = T. | last6 = Moghrabi | first6 = A. | last7 = Mahajan | first7 = A. | last8 = Rutkowski | first8 = S. | last9 = Diez | first9 = B. | title = Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. | journal = J Neurooncol | volume = 95 | issue = 3 | pages = 383-92 | month = Dec | year = 2009 | doi = 10.1007/s11060-009-9936-y | PMID = 19543851 }}</ref> | |||
==IHC== | |||
*CK7+ve. | |||
*CK20-ve (typically). | |||
*S-100+/-. | |||
*EMA-ve. | |||
*GFAP +/-. | |||
*Kir 7.1+ve. | |||
*EAAT1+ve. | |||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
File:Plexuspapillom_Makroskopie.png | Choroid plexus papilloma can become quite large. (WC/marvin101) | |||
File:Plexuspapilloma_intraoperative_smear.jpg | Intraoperative smear of a choroid plexus papilloma. (WC/jensflorian) | |||
Image:Choroid_plexus_papilloma_micrograph.jpg | Choroid plexus papilloma. (WC) | Image:Choroid_plexus_papilloma_micrograph.jpg | Choroid plexus papilloma. (WC) | ||
File:Atypical CPP Ki67 MIB1.jpg | Elevated proliferative activity (MIB-1) in atypical CPP. (WC/marvin101) | |||
</gallery> | </gallery> | ||
www: | www: | ||