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Difference between revisions of "Intracystic papillary breast carcinoma"
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Intracystic papillary breast carcinoma (view source)
Revision as of 14:01, 28 April 2015
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'''Intracystic papillary carcinoma of the breast''', also known as '''encapsulated papillary carcinoma of the breast''' (abbreviated '''EPC'''), is an uncommon type of [[breast cancer]] with a very good prognosis. | |||
==General== | |||
*Very good prognosis<ref name=pmid21753694>{{Cite journal | last1 = Rakha | first1 = EA. | last2 = Gandhi | first2 = N. | last3 = Climent | first3 = F. | last4 = van Deurzen | first4 = CH. | last5 = Haider | first5 = SA. | last6 = Dunk | first6 = L. | last7 = Lee | first7 = AH. | last8 = Macmillan | first8 = D. | last9 = Ellis | first9 = IO. | title = Encapsulated papillary carcinoma of the breast: an invasive tumor with excellent prognosis. | journal = Am J Surg Pathol | volume = 35 | issue = 8 | pages = 1093-103 | month = Aug | year = 2011 | doi = 10.1097/PAS.0b013e31821b3f65 | PMID = 21753694 }}</ref> - it is similar to [[DCIS]]. | *Very good prognosis<ref name=pmid21753694>{{Cite journal | last1 = Rakha | first1 = EA. | last2 = Gandhi | first2 = N. | last3 = Climent | first3 = F. | last4 = van Deurzen | first4 = CH. | last5 = Haider | first5 = SA. | last6 = Dunk | first6 = L. | last7 = Lee | first7 = AH. | last8 = Macmillan | first8 = D. | last9 = Ellis | first9 = IO. | title = Encapsulated papillary carcinoma of the breast: an invasive tumor with excellent prognosis. | journal = Am J Surg Pathol | volume = 35 | issue = 8 | pages = 1093-103 | month = Aug | year = 2011 | doi = 10.1097/PAS.0b013e31821b3f65 | PMID = 21753694 }}</ref> - it is similar to [[DCIS]]. | ||
*Classical menopausal women. | *Classical menopausal women. | ||
*~30% present with bloody discharge.<ref name=pmid21057133>{{Cite journal | last1 = Rodríguez | first1 = MC. | last2 = Secades | first2 = AL. | last3 = Angulo | first3 = JM. | title = Best cases from the AFIP: intracystic papillary carcinoma of the breast. | journal = Radiographics | volume = 30 | issue = 7 | pages = 2021-7 | month = Nov | year = 2010 | doi = 10.1148/rg.307105003 | PMID = 21057133 | URL = http://radiographics.rsnajnls.org/cgi/pmidlookup?view=long&pmid=21057133 }}</ref> | *~30% present with bloody discharge.<ref name=pmid21057133>{{Cite journal | last1 = Rodríguez | first1 = MC. | last2 = Secades | first2 = AL. | last3 = Angulo | first3 = JM. | title = Best cases from the AFIP: intracystic papillary carcinoma of the breast. | journal = Radiographics | volume = 30 | issue = 7 | pages = 2021-7 | month = Nov | year = 2010 | doi = 10.1148/rg.307105003 | PMID = 21057133 | URL = http://radiographics.rsnajnls.org/cgi/pmidlookup?view=long&pmid=21057133 }}</ref> | ||
==Microscopic== | |||
Features: | Features: | ||
*Lesion confined to a cyst. | *Lesion confined to a cyst. | ||
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**Neoplastic epithelial cells: | **Neoplastic epithelial cells: | ||
***[[Nuclear atypia]] - including: nucleoli, [[nuclear pleomorphism]]. | ***[[Nuclear atypia]] - including: nucleoli, [[nuclear pleomorphism]]. | ||
Photos: | Photos: | ||
| Line 100: | Line 94: | ||
*Report only the size of the invasive component (if present) to prevent over-estimation of tumor stage. | *Report only the size of the invasive component (if present) to prevent over-estimation of tumor stage. | ||
==IHC== | |||
*Loss of myoepithelial | *Calponin/p63/SMA/CK5-6. | ||
**Loss of myoepithelial cells within the tumour. | |||
**Loss of myoepithelial cells at the cyst wall. | |||
*ER - Homogeneous staining of the epithelial proliferation. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | |||
[[Category:Invasive breast cancer]] | |||