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Difference between revisions of "Neurodegenerative diseases"
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Jensflorian (talk | contribs) (→Table: update, still incomplete) |
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| cortical & basal ganglia | | cortical & basal ganglia | ||
| dementia (rapid progression), <br>movement disorder | | dementia (rapid progression), <br>movement disorder | ||
| cytoplasmic vacuolization | | cytoplasmic vacuolization, PrP+ve plaques, Kuru plaques (MV2 variant) | ||
| [http://en.wikipedia.org/wiki/File:SpongiformChangeCJD.jpg] | | [http://en.wikipedia.org/wiki/File:SpongiformChangeCJD.jpg] | ||
|- | |- | ||
| [[Parkinson disease]] | | [[Parkinson disease]] | ||
| Line 85: | Line 71: | ||
| brainstem | | brainstem | ||
| parkinsonism | | parkinsonism | ||
| Lewy bodies | | Lewy bodies in substantia nigra and locus coeruleus | ||
| [http://firstaidteam.com/usmlerximages/v/USMLERxLewy+bodies.gif.html] | | [http://firstaidteam.com/usmlerximages/v/USMLERxLewy+bodies.gif.html] [https://de.wikipedia.org/wiki/Datei:LewyBodies_small.JPG] | ||
|- | |- | ||
| [[Dementia with Lewy bodies|Dementia with <br>Lewy bodies]] | | [[Dementia with Lewy bodies|Dementia with <br>Lewy bodies]] | ||
| Line 92: | Line 78: | ||
| corticolimbic, brainstem | | corticolimbic, brainstem | ||
| dementia + parkinsonism | | dementia + parkinsonism | ||
| Lewy bodies | | Lewy bodies brainstem and cortical, tangles | ||
| [http://firstaidteam.com/usmlerximages/v/USMLERxLewy+bodies.gif.html] | | [http://firstaidteam.com/usmlerximages/v/USMLERxLewy+bodies.gif.html] [https://commons.wikimedia.org/wiki/File:DLB_frontal_lewy_bodies_HE.jpg] | ||
|- | |- | ||
| [[Multiple system atrophy]] | | [[Multiple system atrophy]] | ||
| Line 99: | Line 85: | ||
| basal ganglia, brainstem, cerebellum | | basal ganglia, brainstem, cerebellum | ||
| parkinsonism, ataxia | | parkinsonism, ataxia | ||
| cytoplasmic | | Papp-Lantos inclusions (cytoplasmic deposits in oligodendrocytes)<ref>MUN. 15 November 2010.</ref> | ||
| | | [https://commons.wikimedia.org/wiki/File:MSA_Gallays_Papp_Lantos_inclusions.jpg] | ||
|- | |- | ||
| [[Amyotrophic lateral sclerosis|Amyotrophic lateral <br>sclerosis (ALS)]] | | [[Amyotrophic lateral sclerosis|Amyotrophic lateral <br>sclerosis (ALS)]] | ||
| Line 106: | Line 92: | ||
| motor neurons | | motor neurons | ||
| spasticity, weakness | | spasticity, weakness | ||
| | | motor neuron loss, TDP-43+ve, TAF15-ve, EWS-ve inclusions in motor neurons | ||
| | | [https://commons.wikimedia.org/wiki/File:Als_inclusions.png] | ||
|- | |- | ||
| Frontotemporal lobar <br>degeneration (FTLD) | | Frontotemporal lobar <br>degeneration with TDP-43 (FTLD-TDP) | ||
| TDP-43 | | TDP-43 | ||
| cortex, basal ganglia | | cortex, basal ganglia | ||
| dementia, focal cortical syndromes | | dementia, focal cortical syndromes | ||
| histology | | histology depends on (type 1-4), ubiquitin and TDP-43+ve, tau and FUS-ve | ||
| | | [https://commons.wikimedia.org/wiki/File:FTLD_TSP43_hippocampus.jpg] | ||
|- | |||
| Frontotemporal lobar <br>degeneration with FUS (FTLD-FUS) | |||
| FUS | |||
| cortex, medulla, hippocampus, and motor cells of the spinal cord | |||
| dementia, cases classified as FTLD-U, NIFID and BIBD | |||
| FUS+ve, TAF15+ve, EWS+ve cytoplasmic & intranuclear inclusions, neuritic threads | |||
| [http://brain.oxfordjournals.org/content/brain/134/9/2595/F1.medium.gif] | |||
|- | |||
|- | |||
| [[Progressive supranuclear palsy]] (FTLD-tau) | |||
| tau 4R | |||
| basal ganglia, brainstem | |||
| atypical parkinsonism with early gait instability, falls, and supranuclear gaze palsy | |||
| tau-positive globose neurofibrillary tangles <br>in neurons, tufted astrocytes, coiled bodies <br>in oligodendrocytes | |||
| [https://commons.wikimedia.org/wiki/File:PSP_Tau_tufted_astrocyte.jpg] | |||
|- | |||
| [[Pick disease]] (FTLD-tau) | |||
| tau 3R | |||
| corticolimbic | |||
| dementia + focal <br>cortical syndrome | |||
| Intraneuronal argyrophilic inclusions (Pick body) | |||
| [http://frontalcortex.com/gallery/pics/gliageek_PBtau.jpg] | |||
|- | |||
| Corticobasal degeneration (CBD) (FTLD-tau) | |||
| tau 4R | |||
| cortical, basal ganglia | |||
| dementia + movement disorder (Parkinson-plus syndrome) | |||
| ballooned neurons, astrocytic plaques, pretangles in basal nucleus | |||
| [http://webeye.ophth.uiowa.edu/eyeforum/cases-i/case155/4-Progressive-Supranuclear-Palsy-histology.jpg] | |||
|- | |||
| Argryophilic grain disease (AGD) (FTLD-tau) | |||
| tau 4R | |||
| medial temporal lobe, limbic structures | |||
| late-onset amnestic syndrome | |||
| Argyrophilic grains (also found unspecific in elederly) | |||
| [http://de.wikipedia.org/wiki/Silberkornkrankheit#/media/File:AGD_gallays.jpg] | |||
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| Disease | | Disease | ||