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Difference between revisions of "Liver neoplasms"
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→Hepatocellular carcinoma
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*Abbreviated ''HCC''. | *Abbreviated ''HCC''. | ||
{{Main|Hepatocellular carcinoma}} | {{Main|Hepatocellular carcinoma}} | ||
==Biliary Intraductal Papillary Neoplasm<ref>{{Cite journal | Masayuki Ohtsuka, Hiroaki Shimizu, Atsushi Kato, et al., “Intraductal Papillary Neoplasms of the Bile Duct,” International Journal of Hepatology, vol. 2014, Article ID 459091, 10 pages, 2014. doi:10.1155/2014/459091}}</ref>== | |||
===General=== | |||
*Rare | |||
*Highest incidence in Far Eastern countries | |||
*Association with hepatolithiasis and clonorchiasis | |||
*Between 50 and 70 years of age | |||
*Slight male predominance | |||
*Intermittent abdominal pain | |||
*Acute cholangitis | |||
*Jaundice | |||
*Biliary counterpart of [[pancreatic intraductal papillary mucinous neoplasm]] | |||
*Biliary counterpart of [[intracholecystic papillary neoplasm]] (gall bladder) | |||
*Construct consumes some cases of biliary cystadenoma/cystadenocarcinoma, biliary papilloma/papillomatosis, intraductal growth type of cholangiocarcinoma and papillary carcinoma of the extrahepatic bile duct. | |||
===Radiology=== | |||
*Bile duct dilatation | |||
*Intraductal masses | |||
===Gross=== | |||
*Singular, or occasionally multiple, polypoid masses extending into the lumen of a dilated bile duct | |||
*Or multilocular well-defined cystic mass containing mucinous fluid | |||
*Granular or papillary mucosa | |||
*Communication with bile duct may be difficult to confirm | |||
===Microscopic=== | |||
*Papillary or villous growth within the lumen of an intra or extrahepatic bile duct | |||
*Papillary fronds with fine vascular cores | |||
*Epithelium types | |||
**Pancreatobiliary | |||
**Intestinal - marked mucin secretion | |||
**Gastric | |||
**Oncocytic types | |||
*Dysplasia | |||
**High or low grade | |||
**Marked variation in histologic grade between different regions of individual tumors | |||
*Common association with invasive cholangiocarcinoma | |||
**Tubular adenocarcinoma | |||
**Mucinous (colloid) carcinoma (often in association with the intestinal type). | |||
Notes - | |||
*Reflect on the known marked variation in histologic grade between different regions of individual tumors when rendering an opinion on a small biopsy specimen. | |||
*Consider the possibility of an invasive component and submit tissue generously. | |||
==Cholangiocarcinoma== | ==Cholangiocarcinoma== | ||