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Difference between revisions of "Papillary thyroid carcinoma"
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Papillary thyroid carcinoma (view source)
Revision as of 12:33, 30 March 2015
, 12:33, 30 March 2015→Microscopic
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</gallery> | </gallery> | ||
IHC | |||
DDX: | |||
*Papillary thyroid carcinoma | |||
*Papillary thyroid carcinoma, tall cell variant | |||
=====IHC===== | |||
CDX2 - Highlights the morules (CDX2 is positive in the biotin rich nuclei associated with morule formation in a variety of situations)<ref>{{Cite journal | last1 = Wani | first1 = Y. | last2 = Notohara | first2 = K. | last3 = Nakatani | first3 = Y. | last4 = Matsuzaki | first4 = A. | title = Aberrant nuclear Cdx2 expression in morule-forming tumours in different organs, accompanied by cytoplasmic reactivity. | journal = Histopathology | volume = 55 | issue = 4 | pages = 465-8 | month = Oct | year = 2009 | doi = 10.1111/j.1365-2559.2009.03382.x | PMID = 19817898 }}</ref> | CDX2 - Highlights the morules (CDX2 is positive in the biotin rich nuclei associated with morule formation in a variety of situations)<ref>{{Cite journal | last1 = Wani | first1 = Y. | last2 = Notohara | first2 = K. | last3 = Nakatani | first3 = Y. | last4 = Matsuzaki | first4 = A. | title = Aberrant nuclear Cdx2 expression in morule-forming tumours in different organs, accompanied by cytoplasmic reactivity. | journal = Histopathology | volume = 55 | issue = 4 | pages = 465-8 | month = Oct | year = 2009 | doi = 10.1111/j.1365-2559.2009.03382.x | PMID = 19817898 }}</ref> | ||
CD10 - Highlights the morules | CD10 - Highlights the morules <ref>{{Cite journal | last1 = Cameselle-Teijeiro | first1 = J. | last2 = Alberte-Lista | first2 = L. | last3 = Chiarelli | first3 = S. | last4 = Buriticá | first4 = C. | last5 = Gonçalves | first5 = L. | last6 = González-Cámpora | first6 = R. | last7 = Nogales | first7 = FF. | title = CD10 is a characteristic marker of tumours forming morules with biotin-rich, optically clear nuclei that occur in different organs. | journal = Histopathology | volume = 52 | issue = 3 | pages = 389-92 | month = Feb | year = 2008 | doi = 10.1111/j.1365-2559.2007.02911.x | PMID = 18081818 }}</ref> | ||
Beta-catenin - nuclear and cytoplasmic - all tumour cells. | Beta-catenin - nuclear and cytoplasmic - all tumour cells. | ||
TTF-1 - positive | TTF-1 - positive | ||
* | =====Molecular===== | ||
*Papillary | *Up-regulating disturbances in the Wnt signaling pathway promote formation of morules with optically clear biotin rich nuclei <ref>{{Cite journal | last1 = Gamachi | first1 = A. | last2 = Kashima | first2 = K. | last3 = Daa | first3 = T. | last4 = Nakatani | first4 = Y. | last5 = Tsujimoto | first5 = M. | last6 = Yokoyama | first6 = S. | title = Aberrant intranuclear localization of biotin, biotin-binding enzymes, and beta-catenin in pregnancy-related endometrium and morule-associated neoplastic lesions. | journal = Mod Pathol | volume = 16 | issue = 11 | pages = 1124-31 | month = Nov | year = 2003 | doi = 10.1097/01.MP.0000092953.20717.48 | PMID = 14614052 }}</ref> | ||
**Mutation of the beta-catenin gene | |||
**Mutation in APC | |||
*Examples | |||
***Well-differentiated fetal adenocarcinoma | |||
***Papillary carcinoma, cribriform morular variant | |||
***Pancreatoblastoma | |||
====Papillary thyroid carcinoma diffuse sclerosing variant==== | ====Papillary thyroid carcinoma diffuse sclerosing variant==== | ||