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Difference between revisions of "Salivary glands"
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→Adenoid cystic carcinoma: more
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(→Adenoid cystic carcinoma: more) |
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*AKA ''cylindroma''.<ref>Chest. May 1957. Vol. 31. No. 5. PP. 493-511. [http://www.chestjournal.org/content/31/5/493.abstract http://www.chestjournal.org/content/31/5/493.abstract]</ref> | *AKA ''cylindroma''.<ref>Chest. May 1957. Vol. 31. No. 5. PP. 493-511. [http://www.chestjournal.org/content/31/5/493.abstract http://www.chestjournal.org/content/31/5/493.abstract]</ref> | ||
**Should ''not'' be confused with ''dermal cylindroma'' (a benign skin tumour). | **Should ''not'' be confused with ''dermal cylindroma'' (a benign skin tumour). | ||
*Composed of ductal cells and myoepithelial cells; myoepithelial cells > ductal cells. | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Cribriform architecture. | *Cribriform architecture (classic). | ||
*Scant cytoplasm. | **Others: solid, cords, (bilayered) tubules. | ||
* | *Scant cytoplasm - eosinophilic to clear. | ||
*Nucleus - "bland" (small). | |||
**May be angulated (carrot-shaped). | |||
*Hyaline stroma. | *Hyaline stroma. | ||
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Memory device: | Memory device: | ||
*A'''d'''CC - mostly '''D'''NA (scant cytoplasm), distinct nucleus (carrot-shaped). | *A'''d'''CC - mostly '''D'''NA (scant cytoplasm), distinct nucleus (carrot-shaped). | ||
Notes: | |||
*Squamous differentiation is extremely rare. It presence should prompt consideration of: | |||
**Basaloid SCC, basal cell carcinoma (BCC). | |||
====Grading==== | ====Grading==== | ||
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*CD117 +ve. | *CD117 +ve. | ||
*Cyclin D1 +ve. | *Cyclin D1 +ve. | ||
*Myoepithelial markers (e.g. calponin, actin) +ve. | |||
**Typically -ve in PLGA. | |||
==Salivary duct carcinoma== | ==Salivary duct carcinoma== | ||