Difference between revisions of "Medullary thyroid carcinoma"

Other thyroid tumor

*[[Anaplastic thyroid carcinoma]].

*[[Papillary thyroid carcinoma]].

*[[Hurthle cell carcinoma]]

**The oncocytic variant of medullary carcinoma can be confused with Hurthle cell carcinoma. Clues to suggest medullary carcinoma:

***Cytoplasm is amphophilic as opposed to eosinophilic  

***Nests of tumour cells separated by fibrous septa

*[[C-cell hyperplasia]]

**Invasive medullary carcinoma shows fibrosis around tumor cells and stains more weakly for calcitonin.

Other neuroendocrine tumor (primary or metastatic)

*[[Paraganglioma]] - Negative for keratin, calcitonin and CEA

*[[Carcinoid]] - Negative for calcitonin

And of course

*[[Melanoma]] -

**Pigment -  

**Melanoma markers positive, calcitonin and CEA negative.