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Difference between revisions of "Mucinous breast carcinoma"
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*Malignant mucin producing glands. | *Malignant mucin producing glands. | ||
**Mucinous component must comprise >90% of the tumour - '''required for diagnosis'''.<ref name=pmid22006768>{{Cite journal | last1 = Dogan | first1 = E. | last2 = Aksoy | first2 = S. | last3 = Dizdar | first3 = O. | last4 = Arslan | first4 = C. | last5 = Dede | first5 = DS. | last6 = Ozisik | first6 = Y. | last7 = Altundag | first7 = K. | title = Pure mucinous carcinoma of the breast: a single center experience. | journal = J BUON | volume = 16 | issue = 3 | pages = 565-7 | month = | year = | doi = | PMID = 22006768 }}</ref> | **Mucinous component must comprise >90% of the tumour - '''required for diagnosis'''.<ref name=pmid22006768>{{Cite journal | last1 = Dogan | first1 = E. | last2 = Aksoy | first2 = S. | last3 = Dizdar | first3 = O. | last4 = Arslan | first4 = C. | last5 = Dede | first5 = DS. | last6 = Ozisik | first6 = Y. | last7 = Altundag | first7 = K. | title = Pure mucinous carcinoma of the breast: a single center experience. | journal = J BUON | volume = 16 | issue = 3 | pages = 565-7 | month = | year = | doi = | PMID = 22006768 }}</ref> | ||
** | **Small clusters of cells should float in the mucin - '''key feature'''. | ||
**Glands typically have irregular edges. | **Glands typically have irregular edges. | ||
**+/-Vessels within the mucin pools. | **+/-Vessels within the mucin pools. | ||
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*[[DCIS]] with a mucinous component. | *[[DCIS]] with a mucinous component. | ||
**Mucin has a homogenous appearance, mucin lacks vascularization, mucin pools have a regular border. | **Mucin has a homogenous appearance, mucin lacks vascularization, mucin pools have a regular border. | ||
*[[Invasive ductal carcinoma of the breast]] with a mucinous component - more common than ''mucinous breast carcinoma''. | *[[Invasive ductal carcinoma of the breast]] with a mucinous component - more common than ''mucinous breast carcinoma''. Any 'no special type' component imparts a worse prognosis so the diagnosis 'mucinous carcinoma' is reserved for tumours with pure mucinous features. | ||
Note: | Note: | ||
*The amount of mucinous component to call ''[[mucinous carcinoma]]'' varies by anatomical site. | *The amount of mucinous component to call ''[[mucinous carcinoma]]'' varies by anatomical site. | ||
* | *A breast core biopsy that show any degree of mucinous change is an indication for excision to exclude mucinous carcinoma.<ref name=pmid12218567>{{Cite journal | last1 = Jacobs | first1 = TW. | last2 = Connolly | first2 = JL. | last3 = Schnitt | first3 = SJ. | title = Nonmalignant lesions in breast core needle biopsies: to excise or not to excise? | journal = Am J Surg Pathol | volume = 26 | issue = 9 | pages = 1095-110 | month = Sep | year = 2002 | doi = | PMID = 12218567 }}</ref> | ||
*Size and margins are assessed from edge of mucin, even if it does not contain epithelial cells | |||
*These tumors can be very difficult to assess lymphovascular invasion. Look for tumour cells in areas where lymphatics are expected ie. tumour in arc-shape around vascular bundle | |||
===Images=== | ===Images=== | ||