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Difference between revisions of "Medullary thyroid carcinoma"
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Medullary thyroid carcinoma (view source)
Revision as of 03:50, 23 March 2015
, 03:50, 23 March 2015→Microscopic
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DDx: | DDx: | ||
Other thyroid tumor | |||
*[[Anaplastic thyroid carcinoma]]. | *[[Anaplastic thyroid carcinoma]]. | ||
*[[Papillary thyroid carcinoma]]. | *[[Papillary thyroid carcinoma]]. | ||
*[[Hurthle cell carcinoma]] | *[[Hurthle cell carcinoma]] | ||
**The oncocytic variant of medullary carcinoma can be confused with Hurthle cell carcinoma. Clues to suggest medullary carcinoma: | **The oncocytic variant of medullary carcinoma can be confused with Hurthle cell carcinoma. Clues to suggest medullary carcinoma: | ||
***Cytoplasm is amphophilic as opposed to eosinophilic | ***Cytoplasm is amphophilic as opposed to eosinophilic | ||
***Nests of tumour cells separated by fibrous septa | ***Nests of tumour cells separated by fibrous septa | ||
*[[C-cell hyperplasia]] | |||
**Invasive medullary carcinoma shows fibrosis around tumor cells and stains more weakly for calcitonin. | |||
Other neuroendocrine tumor (primary or metastatic) | |||
*[[Paraganglioma]] - Negative for keratin, calcitonin and CEA | |||
*[[Carcinoid]] - Negative for calcitonin | |||
*[[Melanoma]] - | |||
**Pigment - | |||
**Melanoma markers positive, calcitonin and CEA negative. | |||
===Images=== | ===Images=== | ||