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Difference between revisions of "Thyroid gland"
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→Medullary thyroid carcinoma
(→Weird stuff: oncocytic) |
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**C cells (AKA ''parafollicular cell''): abundant cytoplasm - clear/pale. | **C cells (AKA ''parafollicular cell''): abundant cytoplasm - clear/pale. | ||
IHC:<ref>[http://pathologyoutlines.com/thyroid.html#medullary http://pathologyoutlines.com/thyroid.html#medullary]</ref> | Images: | ||
*[http://jcp.bmj.com/content/vol57/issue3/images/large/cp8474.f16.jpeg Medullary thyroid carcinoma (bmj.com)]. | |||
*[http://www.nature.com/ki/journal/v70/n11/fig_tab/5001888f2.html C cell hyperplasia (nature.com)]. | |||
*[http://lifesci.rutgers.edu/~babiarz/Review3/Lp6/scope8.htm C cell (rutgers.edu)]. | |||
*[http://www.anatomyatlases.org/MicroscopicAnatomy/Images/Plate287.jpg Parafollicular cells (anatomyatlases.org)]. | |||
===IHC=== | |||
Features:<ref>URL: [http://pathologyoutlines.com/thyroid.html#medullary http://pathologyoutlines.com/thyroid.html#medullary]. Accessed on: 17 January 2011.</ref> | |||
*[[Calcitonin]] +ve - it arises from C cells (which produce calcitonin). | *[[Calcitonin]] +ve - it arises from C cells (which produce calcitonin). | ||
*Congo-red +ve (amyloid present) - mnemonic: ''CRAP'' -- congo red amyloid protein. | *Congo-red +ve (amyloid present) - mnemonic: ''CRAP'' -- congo red amyloid protein. | ||
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*CEA +ve (often better staining than calcitonin).<ref>SB. 7 January 2010.</ref> | *CEA +ve (often better staining than calcitonin).<ref>SB. 7 January 2010.</ref> | ||
===EM=== | |||
* | *Neurosecretory granules. | ||
* | **Feature seen in neuroendocrine tumours. | ||
Images: [http://pathhsw5m54.ucsf.edu/case7/image77.html Neurosecretory granules (ucsf.edu)]. | |||
==Anaplastic thyroid carcinoma== | ==Anaplastic thyroid carcinoma== | ||