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| *[[AKA]] ''anal squamous carcinoma''. | | *[[AKA]] ''anal squamous carcinoma''. |
| *[[AKA]] ''squamous cell carcinoma of the anus''. | | *[[AKA]] ''squamous cell carcinoma of the anus''. |
| ===General===
| | {{Main|Anal squamous cell carcinoma}} |
| *Most common form of anal cancer.
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| | |
| Risk factors:<ref name=pmid23806153>{{Cite journal | last1 = Kutlubay | first1 = Z. | last2 = Engin | first2 = B. | last3 = Zara | first3 = T. | last4 = Tüzün | first4 = Y. | title = Anogenital malignancies and premalignancies: Facts and controversies. | journal = Clin Dermatol | volume = 31 | issue = 4 | pages = 362-73 | month = | year = | doi = 10.1016/j.clindermatol.2013.01.003 | PMID = 23806153 }}</ref>
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| *Men who have sex with men.
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| *Immunosuppressed.
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| *[[HIV]] infection.
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| ===Microscopic===
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| Features:
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| *See ''[[squamous cell carcinoma]]''.
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| | |
| <gallery>
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| Image:Anus SquamousCellCarcinoma SCC NonKeratinizing AIA SCCIS CTR.jpg|Anus Squamous Cell Carcinoma (Non Keratinizing) - (SKB)
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| Image:Anus SquamousCellCarcinoma SCC NonKeratinizing MP CTR.jpg|Anus Squamous Cell Carcinoma (Non Keratinizing) - (SKB)
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| Image:Anus SquamousCellCarcinoma SCC NonKeratinizing MP4 CTR.jpg|Anus Squamous Cell Carcinoma (Non Keratinizing or shall we say poorly keratinizing as there are squamatized nests focally at high power) - (SKB)
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| </gallery>
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| DDx:
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| *[[Anal gland adenocarcinoma]].
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| *Poorly differentiated [[rectal adenocarcinoma]].
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| | |
| ===IHC===
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| *p16 +ve.<ref name=pmid23105122/>
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| *CDX2 -ve/+ve.
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| **May be useful to differentiate from vulva and penis.<ref name=pmid23105122>{{Cite journal | last1 = Gunia | first1 = S. | last2 = Koch | first2 = S. | last3 = May | first3 = M. | title = Is CDX2 immunostaining useful for delineating anorectal from penile/vulvar squamous cancer in the setting of squamous cell carcinoma with clinically unknown primary site presenting with histologically confirmed inguinal lymph node metastasis? | journal = J Clin Pathol | volume = 66 | issue = 2 | pages = 109-12 | month = Feb | year = 2013 | doi = 10.1136/jclinpath-2012-201138 | PMID = 23105122 }}</ref>
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| | |
| ===Sign out===
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| <pre>
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| RECTUM, DISTAL, BIOPSY:
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| - INVASIVE SQUAMOUS CELL CARCINOMA.
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| </pre>
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|
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| ==Anal gland adenocarcinoma== | | ==Anal gland adenocarcinoma== |