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**Pagetoid squamous cell carcinoma in situ can look identical to extramammary Paget disease | **Pagetoid squamous cell carcinoma in situ can look identical to extramammary Paget disease | ||
**But should have some areas of typical SCCIS with full thickness cohesive atypia | **But should have some areas of typical SCCIS with full thickness cohesive atypia | ||
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Image:Skin SCCIS PagetoidandConventional 15BR30103.jpg|An SCCIS from sundamaged skin. Pagetoid SCCIS on the left, conventional SCCIS on the right. (SKB) | |||
Image:Skin MMIS HP 14PY***.jpg|Melanoma in situ - notice that the atypical cells are largely down at the basal layer with some upward migration. (SKB) | |||
</gallery> | |||
*Pagetoid vulvar/anal/penil HPV associated intraepithelial neoplasia - Pagetoid areas often merge into areas of typical VIN | *Pagetoid vulvar/anal/penil HPV associated intraepithelial neoplasia - Pagetoid areas often merge into areas of typical VIN | ||
*'Paget disease' associated with an underlying local carcinoma - apocrine, Bartholin's duct etc (rare). | *'Paget disease' associated with an underlying local carcinoma - apocrine, Bartholin's duct etc (rare). |
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