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Difference between revisions of "Extramammary Paget disease"
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===DDx=== | ===DDx=== | ||
*[[Malignant melanoma in situ]] - atypical cells are mostly basilar with upward migration. | *[[Malignant melanoma in situ]] - atypical cells are mostly basilar with upward migration. | ||
*[[Bowen disease]] - Pagetoid squamous cell carcinoma in situ - should have some areas of typical SCCIS with full thickness cohesive atypia | *Squamous cell carcinoma in situ "[[Bowen disease]]" - Pagetoid squamous cell carcinoma in situ can look identical to extramammary Paget disease - should have some areas of typical SCCIS with full thickness cohesive atypia | ||
*Pagetoid vulvar intraepithelial neoplasia - Pagetoid areas often merge into areas of typical VIN | *Pagetoid vulvar/anal/penil HPV associated intraepithelial neoplasia - Pagetoid areas often merge into areas of typical VIN | ||
*Notice that mammary Paget disease and Toker cell hyperplasia are not part of this DDX (wrong | *Notice that mammary Paget disease and Toker cell hyperplasia are not part of this DDX (wrong location) except possibly in the rare case of EMPD arising in the axilla where mammary Paget disease arising from a ectopic nipple or ectopic breast tissue may be a consideration. | ||
*Notice that EMPD is not really part of the DDX of pagetoid cutaneous squamous cell carcinoma arising on typical sun damaged skin (arm, cheek, leg) - if it's not from an apocrine rich area (and these are usually in the shade) - it's not EMPD. | *Notice that EMPD is not really part of the DDX of pagetoid cutaneous squamous cell carcinoma arising on typical sun damaged skin (arm, cheek, leg) - if it's not from an apocrine rich area (and these are usually in the shade) - it's not EMPD. | ||