653
edits
Difference between revisions of "Extramammary Paget disease"
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→DDx
(→IHC) |
(→DDx) |
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===DDx=== | ===DDx=== | ||
*[[Malignant melanoma in situ]]. | *[[Malignant melanoma in situ]] - atypical cells are mostly basilar with upward migration. | ||
*[[Bowen disease]] - Pagetoid squamous cell carcinoma in situ | *[[Bowen disease]] - Pagetoid squamous cell carcinoma in situ - should have some areas of typical SCCIS with full thickness cohesive atypia | ||
*Pagetoid vulvar intraepithelial neoplasia | *Pagetoid vulvar intraepithelial neoplasia - Pagetoid areas often merge into areas of typical VIN | ||
*[[Vulvar squamous cell carcinoma]]. | *[[Vulvar squamous cell carcinoma]] - should have some areas of typical SCCIS with full thickness atypia. | ||
Notice that mammary Paget disease and Toker cell hyperplasia are not part of this DDX (wrong locations) except possibly in the rare case of EMPD arising in the axilla where mammary arising from a ectopic nipple or ectopic breast tissue may be a consideration. | *Notice that mammary Paget disease and Toker cell hyperplasia are not part of this DDX (wrong locations) except possibly in the rare case of EMPD arising in the axilla where mammary Paget disease arising from a ectopic nipple or ectopic breast tissue may be a consideration. | ||
Notice that EMPD is not really part of the DDX of pagetoid cutaneous squamous cell carcinoma arising on typical sun damaged skin (arm, cheek, leg) - if it's from an apocrine rich area - it's not EMPD. | *Notice that EMPD is not really part of the DDX of pagetoid cutaneous squamous cell carcinoma arising on typical sun damaged skin (arm, cheek, leg) - if it's from an apocrine rich area - it's not EMPD. | ||
==Stains== | ==Stains== | ||