653
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Difference between revisions of "Extramammary Paget disease"
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→Microscopic
(→Gross) |
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*Epitheliod morphology (round/ovoid). | *Epitheliod morphology (round/ovoid). | ||
*Cells nested or single. | *Cells nested or single. | ||
*Classically Paget cells ride above the basal cell layer | |||
*But the process can fill the entire epidermis | |||
*Clear/pale cytoplasm '''key feature''' - may also be eosinophilic. | *Clear/pale cytoplasm '''key feature''' - may also be eosinophilic. | ||
*Large nucleoli. | *Large nucleoli. | ||
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===DDx=== | ===DDx=== | ||
*[[Malignant melanoma in situ]]. | |||
*[[Malignant melanoma]]. | *[[Bowen disease]] - Pagetoid squamous cell carcinoma in situ. | ||
*[[Bowen disease]]. | *[[Apocrine carcinoma of the skin]] - really Paget with an underlying apocrine carcinoma.<ref>URL: [http://derm101.com/searchResults.aspx?searchStr=apocrine+carcinoma&rootTerm=apocrine+carcinoma&searchType=2&rootID=12687 http://derm101.com/searchResults.aspx?searchStr=apocrine+carcinoma&rootTerm=apocrine+carcinoma&searchType=2&rootID=12687]. Accessed on: 9 September 2011.</ref> | ||
*[[Apocrine carcinoma of the skin]].<ref>URL: [http://derm101.com/searchResults.aspx?searchStr=apocrine+carcinoma&rootTerm=apocrine+carcinoma&searchType=2&rootID=12687 http://derm101.com/searchResults.aspx?searchStr=apocrine+carcinoma&rootTerm=apocrine+carcinoma&searchType=2&rootID=12687]. Accessed on: 9 September 2011.</ref> | |||
*[[Vulvar squamous cell carcinoma]]. | *[[Vulvar squamous cell carcinoma]]. | ||
*Pagetoid vulvar intraepithelial neoplasia | |||
*Toker cell hyperplasia is really just a nipple (mammary Paget issue). | |||
==Stains== | ==Stains== | ||