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Well-differentiated papillary mesothelioma (view source)
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'''Well-differentiated papillary mesothelioma''', abbreviated '''WDPM''', is a rare type of [[mesothelioma]] that typically has an indolent behaviour.<ref>{{Cite journal | last1 = Butnor | first1 = KJ. | last2 = Sporn | first2 = TA. | last3 = Hammar | first3 = SP. | last4 = Roggli | first4 = VL. | title = Well-differentiated papillary mesothelioma. | journal = Am J Surg Pathol | volume = 25 | issue = 10 | pages = 1304-9 | month = Oct | year = 2001 | doi = | PMID = 11688466 }}</ref> | |||
It is also known as '''benign papillary mesothelioma'''. It should '''not''' be confused with ''[[malignant mesothelioma]]'' or ''[[benign multicystic mesothelioma]]''. | |||
==General== | |||
*Benign. | |||
**Some say it is ''borderline''.<ref name=pmid2122588>{{Cite journal | last1 = Bürrig | first1 = KF. | last2 = Pfitzer | first2 = P. | last3 = Hort | first3 = W. | title = Well-differentiated papillary mesothelioma of the peritoneum: a borderline mesothelioma. Report of two cases and review of literature. | journal = Virchows Arch A Pathol Anat Histopathol | volume = 417 | issue = 5 | pages = 443-7 | month = | year = 1990 | doi = | PMID = 2122588 }}</ref> | |||
*Classically women of reproductive age.<ref name=pmid18716115>{{Cite journal | last1 = Park | first1 = JY. | last2 = Kim | first2 = KW. | last3 = Kwon | first3 = HJ. | last4 = Park | first4 = MS. | last5 = Kwon | first5 = GY. | last6 = Jun | first6 = SY. | last7 = Yu | first7 = ES. | title = Peritoneal mesotheliomas: clinicopathologic features, CT findings, and differential diagnosis. | journal = AJR Am J Roentgenol | volume = 191 | issue = 3 | pages = 814-25 | month = Sep | year = 2008 | doi = 10.2214/AJR.07.3628 | PMID = 18716115 | URL = content/191/3/814.full.pdf}}</ref> | |||
*Reported in tunica vaginalis of the [[testis]].<ref name=pmid1452778>{{Cite journal | last1 = Chetty | first1 = R. | title = Well differentiated (benign) papillary mesothelioma of the tunica vaginalis. | journal = J Clin Pathol | volume = 45 | issue = 11 | pages = 1029-30 | month = Nov | year = 1992 | doi = | PMID = 1452778 }}</ref> | |||
==Gross== | |||
Features - typical: | |||
*Multiple peritoneal nodules. | |||
*Ascites. | |||
DDx:<ref name=pmid18716115/> | |||
*[[Tuberculosis]]. | |||
*Carcinomatosis. | |||
*[[Primary peritoneal serous carcinoma]]. | |||
==Microscopic== | |||
Features: | |||
*Papillary structures with: | |||
**Thick fibrous cores. | |||
**Simple cuboidal epithelium. | |||
***Small nucleoli. | |||
Note: | |||
*Lack cytologic atypia. | |||
DDx:<ref>{{Cite journal | last1 = Truong | first1 = LD. | last2 = Maccato | first2 = ML. | last3 = Awalt | first3 = H. | last4 = Cagle | first4 = PT. | last5 = Schwartz | first5 = MR. | last6 = Kaplan | first6 = AL. | title = Serous surface carcinoma of the peritoneum: a clinicopathologic study of 22 cases. | journal = Hum Pathol | volume = 21 | issue = 1 | pages = 99-110 | month = Jan | year = 1990 | doi = | PMID = 1688545 }}</ref> | |||
*[[Ovarian serous carcinoma]]. | |||
*[[Serous borderline tumour of the ovary]]. | |||
*[[Malignant mesothelioma]]. | |||
===Images=== | |||
www: | |||
*[http://www.webpathology.com/image.asp?n=10&Case=86 Benign papillary mesothelioma (webpathology.com)]. | |||
==See also== | |||
*[[Peritoneum]]. | |||
*[[Malignant mesothelioma]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Peritoneum]] | |||