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Difference between revisions of "Choriocarcinoma"
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(→IHC) |
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| Symptoms = vaginal bleeding | | Symptoms = vaginal bleeding | ||
| Prevalence = rare | | Prevalence = rare | ||
| Bloodwork = beta-hCG markedly elevated | | Bloodwork = beta-hCG markedly elevated (usu. >10,000 IU) | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Line 36: | Line 36: | ||
===Clinical=== | ===Clinical=== | ||
*High beta-hCG -- usually > 10,000 IU. | *High beta-hCG -- usually > 10,000 IU. | ||
**Median in one series of testicular choriocarcinoma ~ 200,000 IU.<ref name=pmid24145647>{{Cite journal | last1 = Alvarado-Cabrero | first1 = I. | last2 = Hernández-Toriz | first2 = N. | last3 = Paner | first3 = GP. | title = Clinicopathologic analysis of choriocarcinoma as a pure or predominant component of germ cell tumor of the testis. | journal = Am J Surg Pathol | volume = 38 | issue = 1 | pages = 111-8 | month = Jan | year = 2014 | doi = 10.1097/PAS.0b013e3182a2926e | PMID = 24145647 }}</ref> | |||
**Elevation may be seen in other (non-trophoblastic) tumours.<ref name=pmid7690985>{{Cite journal | last1 = Mann | first1 = K. | last2 = Saller | first2 = B. | last3 = Hoermann | first3 = R. | title = Clinical use of HCG and hCG beta determinations. | journal = Scand J Clin Lab Invest Suppl | volume = 216 | issue = | pages = 97-104 | month = | year = 1993 | doi = | PMID = 7690985 }}</ref> | |||
*Vaginal bleeding. | *Vaginal bleeding. | ||
*Occasionally thyrotoxicosis.<ref name=pmid8395487>{{Cite journal | last1 = O'Reilly | first1 = S. | last2 = Lyons | first2 = DJ. | last3 = Harrison | first3 = M. | last4 = Gaffney | first4 = E. | last5 = Cullen | first5 = M. | last6 = Clancy | first6 = L. | title = Thyrotoxicosis induced by choriocarcinoma a report of two cases. | journal = Ir Med J | volume = 86 | issue = 4 | pages = 124, 127 | month = | year = | doi = | PMID = 8395487 }}</ref> | *Occasionally thyrotoxicosis.<ref name=pmid8395487>{{Cite journal | last1 = O'Reilly | first1 = S. | last2 = Lyons | first2 = DJ. | last3 = Harrison | first3 = M. | last4 = Gaffney | first4 = E. | last5 = Cullen | first5 = M. | last6 = Clancy | first6 = L. | title = Thyrotoxicosis induced by choriocarcinoma a report of two cases. | journal = Ir Med J | volume = 86 | issue = 4 | pages = 124, 127 | month = | year = | doi = | PMID = 8395487 }}</ref> | ||