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Difference between revisions of "Neurodegenerative diseases"
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Neurodegenerative diseases (view source)
Revision as of 18:36, 16 February 2015
, 18:36, 16 February 2015→Common diseases
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[[Amyloid]]oses: | [[Amyloid]]oses: | ||
*Alzheimer disease (Abeta). | *Alzheimer disease (Abeta). | ||
'Pure' tauopathies: | |||
*[[Progressive supranuclear palsy]]. | *[[Progressive supranuclear palsy]]. | ||
*[[Pick's disease]]. | *[[Pick's disease]]. | ||
*Corticobasal degeneration | |||
*FTDP-17 | |||
*Dementia pugilistica | |||
Synucleinopathies:<ref name=pmid18855701>{{Cite journal | last1 = Uversky | first1 = VN. | title = Alpha-synuclein misfolding and neurodegenerative diseases. | journal = Curr Protein Pept Sci | volume = 9 | issue = 5 | pages = 507-40 | month = Oct | year = 2008 | doi = | PMID = 18855701 }}</ref> | Synucleinopathies:<ref name=pmid18855701>{{Cite journal | last1 = Uversky | first1 = VN. | title = Alpha-synuclein misfolding and neurodegenerative diseases. | journal = Curr Protein Pept Sci | volume = 9 | issue = 5 | pages = 507-40 | month = Oct | year = 2008 | doi = | PMID = 18855701 }}</ref> | ||
| Line 32: | Line 34: | ||
TDP-43 proteinopathies: | TDP-43 proteinopathies: | ||
*[[Amyotrophic lateral sclerosis]]. | *[[Amyotrophic lateral sclerosis]]. | ||
*Frontotemporal lobar degeneration | *Frontotemporal lobar degeneration | ||
FUS proteinopathies: | |||
*[[Amyotrophic lateral sclerosis]]. | |||
*Frontotemporal lobar degeneration | |||
Prionopathies: | |||
*Creutzfeldt-Jakob disease (PrP). | |||
====Table==== | ====Table==== | ||
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| tau 4R | | tau 4R | ||
| basal ganglia, brainstem | | basal ganglia, brainstem | ||
| parkinsonism | | atypical parkinsonism with early gait instability, falls, and supranuclear gaze palsy | ||
| globose neurofibrillary tangles <br>in neurons, coiled bodies <br>in oligodendrocytes | | tau-positive globose neurofibrillary tangles <br>in neurons, tufted astrocytes, coiled bodies <br>in oligodendrocytes | ||
| Image? | | Image? | ||
|- | |- | ||
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| Image | | Image | ||
|- | |- | ||
| Frontotemporal lobar <br>degeneration (FTLD) | | Frontotemporal lobar <br>degeneration (FTLD) | ||
| TDP-43 | | TDP-43 | ||
| cortex, basal ganglia | | cortex, basal ganglia | ||