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Difference between revisions of "Papillary renal cell carcinoma"
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Papillary renal cell carcinoma (view source)
Revision as of 20:39, 13 February 2015
, 20:39, 13 February 2015make all abbrev. 'PaRCC'
(make all abbrev. 'PaRCC') |
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| Micro = cuboidal or low columnar cells (simple or pseudostratified) on papillae, interstitial foam cells in the vascular cores | | Micro = cuboidal or low columnar cells (simple or pseudostratified) on papillae, interstitial foam cells in the vascular cores | ||
| Subtypes = type 1, type 2, oncocytic variant | | Subtypes = type 1, type 2, oncocytic variant | ||
| LMDDx = [[clear cell renal cell carcinoma]], [[clear cell papillary renal cell carcinoma]], [[metanephric adenoma]] (esp. solid | | LMDDx = [[clear cell renal cell carcinoma]], [[clear cell papillary renal cell carcinoma]], [[metanephric adenoma]] (esp. solid PaRCC type 1), [[collecting duct carcinoma]] (esp. PaRCC type 2), [[renal papillary adenoma]], [[acquired cystic disease-associated renal cell carcinoma]], [[urothelial carcinoma]], [[renal mucinous tubular and spindle cell carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
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*Cuboidal or low columnar cell in papillae. | *Cuboidal or low columnar cell in papillae. | ||
*Interstitial foam cells in vascular cores - '''key feature'''. | *Interstitial foam cells in vascular cores - '''key feature'''. | ||
**Most sensitive and specific feature of | **Most sensitive and specific feature of PaRCC.<ref>{{cite journal |author=Granter SR, Perez-Atayde AR, Renshaw AA |title=Cytologic analysis of papillary renal cell carcinoma |journal=Cancer |volume=84 |issue=5 |pages=303?8 |year=1998 |month=October |pmid=9801205 |doi= |url=http://dx.doi.org/10.1002/(SICI)1097-0142(19981025)84:5<303::AID-CNCR6>3.0.CO;2-7}}</ref> | ||
*Highly vascular. | *Highly vascular. | ||
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**Papillary: histiocytes, intracellular hemosiderin, [[CK7]] +ve. | **Papillary: histiocytes, intracellular hemosiderin, [[CK7]] +ve. | ||
*[[Clear cell papillary renal cell carcinoma]] - apical nuclei, usu. no true papillae. | *[[Clear cell papillary renal cell carcinoma]] - apical nuclei, usu. no true papillae. | ||
*[[Metanephric adenoma]] (esp. solid | *[[Metanephric adenoma]] (esp. solid PaRCC type 1) - no histiocytes, WT-1 +ve. | ||
*[[Collecting duct carcinoma]] - esp. | *[[Collecting duct carcinoma]] - esp. PaRCC type 2. | ||
*[[Urothelial carcinoma]]. | *[[Urothelial carcinoma]]. | ||
*[[Renal papillary adenoma]] - doesn't fulfill size criterion for PaRCC. | *[[Renal papillary adenoma]] - doesn't fulfill size criterion for PaRCC. | ||