Difference between revisions of "Reactive changes"

Reactive changes (view source)

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-#redirect [[Uterine_cervix#Reactive_squamous_epithelium_of_the_uterine_cervix]]
+'''Reactive changes''' is a commonly used term that implies:
+# Inflammation.
+# Nuclear changes compatible with inflammation.
+==General==
+Nuclear changes are seen in:
+*Inflammatory processes.
+*Repair.
+*Neoplastic processes.
+The line between a reactive process and a neoplastic process may be fuzzy. In the context of inflammation, nuclear changes are typically present and the threshold for calling suspicious or malignancy is typically higher.
+==Microscopic==
+Features - generic:
+*Nuclear changes:
+**Nuclear enlargement.
+**Nuclear hyperchromasia.
+**Prominent nucleoli.
+*Inflammation - acute and/or chronic.
+DDx:
+*[[Waffle diagnosis]] (e.g. [[indefinite for dysplasia]]) - nuclear changes of unknown significance.
+**Terminology dependent on the anatomical site.
+*[[Nuclear atypia]].
+**This is often qualified as it may represent neoplastic process or a benign process dependent on the context.
+**Common qualifiers:
+***Worrisome lesions: "cannot exclude dysplasia", "suspicious for malignancy".
+***Suspected to be benign: "favour benign".
+*[[Malignancy]].
+==See also==
+*[[Reactive atypia]].
+*[[Nuclear atypia]].
+*[[NC ratio]].
+*[[Reactive squamous epithelium of the uterine cervix]].
+[[Category:Stuff]]