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Difference between revisions of "Radiation colitis"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Radiation_proctitis_-_2_alt_--_high_mag.jpg | |||
| Width = | |||
| Caption = Radiation proctitis. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = ''acute'': mucosal changes ([[necrosis]] of epithelium, "ghost cells" = cells without nuclei, hemorrhage), submucosa edema with neutrophilic infiltrate, +/-fibrin thrombi; ''chronic'': nuclear atypia - esp. of the stromal cells, fibrosis - esp. of the submucosa | |||
| Subtypes = | |||
| LMDDx = [[inflammatory bowel disease]], [[Infectious colitis]], [[ischemic colitis]], pseudosarcomatous stromal changes, [[sarcoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[colon]] and [[rectum]] (''radiation proctitis'') | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = history of radiation, history of [[cancer]] | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = cancer recurrence, colitis/proctitis (idiopathic, infection, ischemic, radiation) | |||
| Tx = | |||
}} | |||
'''Radiation [[colitis]]''' is inflammation of the [[colon]] due to radiation. It is usually iatrogenic. This article also covers '''radiation proctitis'''. | '''Radiation [[colitis]]''' is inflammation of the [[colon]] due to radiation. It is usually iatrogenic. This article also covers '''radiation proctitis'''. | ||
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*Telangiectatic lesions. | *Telangiectatic lesions. | ||
Image | ===Image=== | ||
*[http://www.nature.com/nrgastro/journal/v5/n1/fig_tab/ncpgasthep1005_F4.html#figure-title Telangiectatic lesions (nature.com)].<ref name=pmid18174905>{{Cite journal | last1 = Nielsen | first1 = OH. | last2 = Vainer | first2 = B. | last3 = Rask-Madsen | first3 = J. | title = Non-IBD and noninfectious colitis. | journal = Nat Clin Pract Gastroenterol Hepatol | volume = 5 | issue = 1 | pages = 28-39 | month = Jan | year = 2008 | doi = 10.1038/ncpgasthep1005 | PMID = 18174905 }}</ref> | *[http://www.nature.com/nrgastro/journal/v5/n1/fig_tab/ncpgasthep1005_F4.html#figure-title Telangiectatic lesions (nature.com)].<ref name=pmid18174905>{{Cite journal | last1 = Nielsen | first1 = OH. | last2 = Vainer | first2 = B. | last3 = Rask-Madsen | first3 = J. | title = Non-IBD and noninfectious colitis. | journal = Nat Clin Pract Gastroenterol Hepatol | volume = 5 | issue = 1 | pages = 28-39 | month = Jan | year = 2008 | doi = 10.1038/ncpgasthep1005 | PMID = 18174905 }}</ref> | ||
==Microscopic== | ==Microscopic== | ||
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*Infectious colitis. | *Infectious colitis. | ||
Images: | ===Images=== | ||
<gallery> | |||
Image: Radiation proctitis -- very low mag.jpg | RP - very low mag. | |||
Image: Radiation proctitis -- low mag.jpg | RP - low mag. | |||
Image: Radiation proctitis - alt -- low mag.jpg | RP - low mag. | |||
Image: Radiation proctitis -- intermed mag.jpg | RP - intermed. mag. | |||
Image: Radiation proctitis -- high mag.jpg | RP - high mag. | |||
Image: Radiation proctitis -- very high mag.jpg | RP - very high mag. | |||
Image: Radiation proctitis - 2 -- intermed mag.jpg | RP - intermed. mag. | |||
Image: Radiation proctitis - 2 -- high mag.jpg | RP - high mag. | |||
Image: Radiation proctitis - 2 alt -- high mag.jpg | RP - high mag. | |||
Image: Proctitis with reactive changes -- intermed mag.jpg | PRC - intermed. mag. | |||
Image: Proctitis with reactive changes -- high mag.jpg | PRC - high mag. | |||
Image: Proctitis with reactive changes - alt -- high mag.jpg | PRC - high mag. | |||
</gallery> | |||
www: | |||
*[http://gut.bmj.com/content/41/3/354/F2.large.jpg Radiation colitis - rat model (bmj.com)].<ref name=pmid9378391/> | *[http://gut.bmj.com/content/41/3/354/F2.large.jpg Radiation colitis - rat model (bmj.com)].<ref name=pmid9378391/> | ||
*[http://www.nature.com/nrgastro/journal/v5/n1/fig_tab/ncpgasthep1005_F5.html#figure-title Radiation colitis (nature.com)].<ref name=pmid18174905>{{Cite journal | last1 = Nielsen | first1 = OH. | last2 = Vainer | first2 = B. | last3 = Rask-Madsen | first3 = J. | title = Non-IBD and noninfectious colitis. | journal = Nat Clin Pract Gastroenterol Hepatol | volume = 5 | issue = 1 | pages = 28-39 | month = Jan | year = 2008 | doi = 10.1038/ncpgasthep1005 | PMID = 18174905 }}</ref> | *[http://www.nature.com/nrgastro/journal/v5/n1/fig_tab/ncpgasthep1005_F5.html#figure-title Radiation colitis (nature.com)].<ref name=pmid18174905>{{Cite journal | last1 = Nielsen | first1 = OH. | last2 = Vainer | first2 = B. | last3 = Rask-Madsen | first3 = J. | title = Non-IBD and noninfectious colitis. | journal = Nat Clin Pract Gastroenterol Hepatol | volume = 5 | issue = 1 | pages = 28-39 | month = Jan | year = 2008 | doi = 10.1038/ncpgasthep1005 | PMID = 18174905 }}</ref> | ||