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Difference between revisions of "Enteropathy-associated T-cell lymphoma"
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Enteropathy-associated T-cell lymphoma (view source)
Revision as of 08:17, 20 December 2014
, 08:17, 20 December 2014no edit summary
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| Caption = Enteropathy-associated T cell lymphoma. [[H&E stain]]. | | Caption = Enteropathy-associated T cell lymphoma. [[H&E stain]]. | ||
| Synonyms = enteropathy-type T-cell lymphoma | | Synonyms = enteropathy-type T-cell lymphoma | ||
| Micro = large | | Micro = large or medium-sized lymphoid cells in the mucosa and submucosa | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = other lymphomas | ||
| Stains = | | Stains = | ||
| IHC = CD3 +ve, CD5 -ve, CD8 -ve/+ve, CD56 -ve/+ve, CD30 +ve | | IHC = CD3 +ve, CD5 -ve, CD8 -ve/+ve, CD56 -ve/+ve, CD30 +ve | ||
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| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = poor | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = dependent on presentation - other causes of [[SBO]], e.g. [[duodenal adenocarcinoma]] | ||
| Tx = | | Tx = | ||
}} | }} | ||
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*T cell lymphoma due to [[celiac sprue]]. | *T cell lymphoma due to [[celiac sprue]]. | ||
*Subdivided into type I and type II.<ref name=pmid21566094>{{cite journal |author=Delabie J, et al |title=Enteropathy-associated T-cell lymphoma: clinical and histological findings from the International Peripheral T-Cell Lymphoma Project|journal=Blood |volume=118|issue=148|pages= 148|year=2011|month=July}}</ref> | *Subdivided into type I and type II.<ref name=pmid21566094>{{cite journal |author=Delabie J, et al |title=Enteropathy-associated T-cell lymphoma: clinical and histological findings from the International Peripheral T-Cell Lymphoma Project|journal=Blood |volume=118|issue=148|pages= 148|year=2011|month=July}}</ref> | ||
*Poor prognosis.<ref name=pmid23313469>{{Cite journal | last1 = Malamut | first1 = G. | last2 = Chandesris | first2 = O. | last3 = Verkarre | first3 = V. | last4 = Meresse | first4 = B. | last5 = Callens | first5 = C. | last6 = Macintyre | first6 = E. | last7 = Bouhnik | first7 = Y. | last8 = Gornet | first8 = JM. | last9 = Allez | first9 = M. | title = Enteropathy associated T cell lymphoma in celiac disease: a large retrospective study. | journal = Dig Liver Dis | volume = 45 | issue = 5 | pages = 377-84 | month = May | year = 2013 | doi = 10.1016/j.dld.2012.12.001 | PMID = 23313469 }}</ref> | |||
**Five-year survival as low as 20%.<ref name=pmid24876396>{{Cite journal | last1 = Pun | first1 = AH. | last2 = Kasmeridis | first2 = H. | last3 = Rieger | first3 = N. | last4 = Loganathan | first4 = A. | title = Enteropathy associated T-cell lymphoma presenting with multiple episodes of small bowel haemorrhage and perforation. | journal = J Surg Case Rep | volume = 2014 | issue = 3 | pages = | month = | year = 2014 | doi = 10.1093/jscr/rju013 | PMID = 24876396 }}</ref> | |||
Presentations - may include: | |||
*Small bowel obstruction or perforation.<ref name=pmid23555174>{{Cite journal | last1 = Kim | first1 = JB. | last2 = Kim | first2 = SH. | last3 = Cho | first3 = YK. | last4 = Ahn | first4 = SB. | last5 = Jo | first5 = YJ. | last6 = Park | first6 = YS. | last7 = Lee | first7 = JH. | last8 = Kim | first8 = DH. | last9 = Lee | first9 = H. | title = A case of colon perforation due to enteropathy-associated T-cell lymphoma. | journal = World J Gastroenterol | volume = 19 | issue = 11 | pages = 1841-4 | month = Mar | year = 2013 | doi = 10.3748/wjg.v19.i11.1841 | PMID = 23555174 }}</ref> | |||
*GI hemorrhage.<ref name=pmid24876396/> | |||
Treatment: | |||
*Chemotherapy.<ref>{{Cite journal | last1 = Cairoli | first1 = A. | last2 = Ketterer | first2 = N. | last3 = Barelli | first3 = S. | last4 = Duchosal | first4 = MA. | title = High-dose therapy and autologous hematopoietic stem cell transplant in T-cell lymphoma: a single center experience. | journal = Leuk Lymphoma | volume = 55 | issue = 8 | pages = 1827-31 | month = Aug | year = 2014 | doi = 10.3109/10428194.2013.852666 | PMID = 24138331 }}</ref> | |||
*Autologous stem cell transplantation.<ref name=pmid23361910>{{Cite journal | last1 = Jantunen | first1 = E. | last2 = Boumendil | first2 = A. | last3 = Finel | first3 = H. | last4 = Luan | first4 = JJ. | last5 = Johnson | first5 = P. | last6 = Rambaldi | first6 = A. | last7 = Haynes | first7 = A. | last8 = Duchosal | first8 = MA. | last9 = Bethge | first9 = W. | title = Autologous stem cell transplantation for enteropathy-associated T-cell lymphoma: a retrospective study by the EBMT. | journal = Blood | volume = 121 | issue = 13 | pages = 2529-32 | month = Mar | year = 2013 | doi = 10.1182/blood-2012-11-466839 | PMID = 23361910 }}</ref> | |||
==Gross== | ==Gross== | ||