Difference between revisions of "Tuberous sclerosis-associated renal cell carcinoma"

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==General==
==General==
*Not in the [[WHO classification of renal neoplasia]] or the [[Vancouver classification|Vancouver modification of the WHO classification]].
*Not in the [[WHO classification of renal neoplasia]] or the [[Vancouver classification|Vancouver modification of the WHO classification]].
*Afflicts individuals at a younger age than sporadic [[renal cell carcinoma]]<ref name=pmid8863669>{{Cite journal  | last1 = Bjornsson | first1 = J. | last2 = Short | first2 = MP. | last3 = Kwiatkowski | first3 = DJ. | last4 = Henske | first4 = EP. | title = Tuberous sclerosis-associated renal cell carcinoma. Clinical, pathological, and genetic features. | journal = Am J Pathol | volume = 149 | issue = 4 | pages = 1201-8 | month = Oct | year = 1996 | doi =  | PMID = 8863669 }}</ref> - average age of 36 years.<ref name=pmid9827727>{{cite journal |author=Al-Saleem T, Wessner LL, Scheithauer BW, ''et al.'' |title=Malignant tumors of the kidney, brain, and soft tissues in children and young adults with the tuberous sclerosis complex |journal=Cancer |volume=83 |issue=10 |pages=2208–16 |year=1998 |month=November |pmid=9827727 |doi= |url=}}</ref>
*Afflicts individuals at a younger age than sporadic [[renal cell carcinoma]].<ref name=pmid8863669>{{Cite journal  | last1 = Bjornsson | first1 = J. | last2 = Short | first2 = MP. | last3 = Kwiatkowski | first3 = DJ. | last4 = Henske | first4 = EP. | title = Tuberous sclerosis-associated renal cell carcinoma. Clinical, pathological, and genetic features. | journal = Am J Pathol | volume = 149 | issue = 4 | pages = 1201-8 | month = Oct | year = 1996 | doi =  | PMID = 8863669 }}</ref>
*2-4% of individual with tuberous sclerosis develop renal cell carcinoma.<ref name=pmid24832166>{{Cite journal  | last1 = Yang | first1 = P. | last2 = Cornejo | first2 = KM. | last3 = Sadow | first3 = PM. | last4 = Cheng | first4 = L. | last5 = Wang | first5 = M. | last6 = Xiao | first6 = Y. | last7 = Jiang | first7 = Z. | last8 = Oliva | first8 = E. | last9 = Jozwiak | first9 = S. | title = Renal cell carcinoma in tuberous sclerosis complex. | journal = Am J Surg Pathol | volume = 38 | issue = 7 | pages = 895-909 | month = Jul | year = 2014 | doi = 10.1097/PAS.0000000000000237 | PMID = 24832166 }}</ref>
*2-4% of individual with tuberous sclerosis develop renal cell carcinoma.<ref name=pmid24832166>{{Cite journal  | last1 = Yang | first1 = P. | last2 = Cornejo | first2 = KM. | last3 = Sadow | first3 = PM. | last4 = Cheng | first4 = L. | last5 = Wang | first5 = M. | last6 = Xiao | first6 = Y. | last7 = Jiang | first7 = Z. | last8 = Oliva | first8 = E. | last9 = Jozwiak | first9 = S. | title = Renal cell carcinoma in tuberous sclerosis complex. | journal = Am J Surg Pathol | volume = 38 | issue = 7 | pages = 895-909 | month = Jul | year = 2014 | doi = 10.1097/PAS.0000000000000237 | PMID = 24832166 }}</ref>


==Microscopic==
==Microscopic==
Features as per Guo ''et al.''<ref name=pmid25093518/> describes three different morphologies:
Features as per Guo ''et al.''<ref name=pmid25093518/> describes three different morphologies:
#[[Renal angiomyoadenomatous tumour]]-like.
*#[[Renal angiomyoadenomatous tumour]]-like.
#[[Chromophobe renal cell carcinoma]]-like.
*#[[Chromophobe renal cell carcinoma]]-like.
#Macrocystic architecture composed of cells with a granular eosinophilic cytoplasm.
*#Macrocystic architecture composed of cells with a granular eosinophilic cytoplasm.


Notes:
Notes:
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