Difference between revisions of "Neuropathology tumours"

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Neuropathology tumours (view source)

Revision as of 07:04, 9 December 2014

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→‎Dysembryoplastic neuroepithelial tumour: split out
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==Dysembryoplastic neuroepithelial tumour==
==Dysembryoplastic neuroepithelial tumour==
*Abbreviated ''DNT''.
*Abbreviated ''DNT''.
 
{{Main|Dysembryoplastic neuroepithelial tumour}}
===General===
*Common tumour cause of drug resistant epilepsy.<ref name=pmid15881751>{{Cite journal  | last1 = Cataltepe | first1 = O. | last2 = Turanli | first2 = G. | last3 = Yalnizoglu | first3 = D. | last4 = Topçu | first4 = M. | last5 = Akalan | first5 = N. | title = Surgical management of temporal lobe tumor-related epilepsy in children. | journal = J Neurosurg | volume = 102 | issue = 3 Suppl | pages = 280-7 | month = Apr | year = 2005 | doi = 10.3171/ped.2005.102.3.0280 | PMID = 15881751 }}</ref>
*Paediatric population.
 
===Gross/radiology===
*Temporal lobe.
*Variable architecture:<ref name=pmid18071981/> cystic, solitary nodular, multinodular.
 
===Microscopic===
Features:<ref name=pmid18071981>{{Cite journal  | last1 = O'Brien | first1 = DF. | last2 = Farrell | first2 = M. | last3 = Delanty | first3 = N. | last4 = Traunecker | first4 = H. | last5 = Perrin | first5 = R. | last6 = Smyth | first6 = MD. | last7 = Park | first7 = TS. | title = The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours. | journal = Br J Neurosurg | volume = 21 | issue = 6 | pages = 539-49 | month = Dec | year = 2007 | doi = 10.1080/02688690701594817 | PMID = 18071981 }}</ref>
*Cells similar to oligodendrocytes:
**Large central nuclei with indentations.
**Multiple small nucleoli (common).
**Clear cytoplasm.
 
DDx:
*[[Oligodendroglioma]].
**These have rounder, smaller nuclei with occasional nucleoli.<ref name=pmid18071981/>
 
Images:
*[http://commons.wikimedia.org/wiki/File:DNET_HE.jpg DNT (WC)].
*[http://path.upmc.edu/cases/case106.html DNT - several images (upmc.edu)].


==Subependymal giant cell astrocytoma==
==Subependymal giant cell astrocytoma==
Michael
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