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Difference between revisions of "Squamous dysplasia of the head and neck"
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Squamous dysplasia of the head and neck (view source)
Revision as of 04:49, 5 December 2014
, 04:49, 5 December 2014→Ljubljana system
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*High-grade SIL. | *High-grade SIL. | ||
*Carcinoma in situ. | *Carcinoma in situ. | ||
Low-grade squamous intraepithelial lesion:<ref name=pmid24689850/> | |||
*Increased prickle cell layer. | |||
*+/-Thickening of basal and/or parabasal cell layers. | |||
*No significant [[nuclear atypia]]. | |||
*Rare mitotic figures. | |||
*Dyskeratotic cells - rare. | |||
*Must show maturation to surface. | |||
High-grade squamous intraepithelial lesion:<ref name=pmid24689850/> | |||
*Long axis perpendicular to basement membrane. | |||
*Lower half or more abnormal. | |||
*[[Nuclear pleomorphism]] present. | |||
**Irregular nuclear contours. | |||
**Hyperchromasia. | |||
**Nucleoli increased in size and number. | |||
*Increased [[NC ratio]]. | |||
*Mitotic activity in predominantly in the lower 2/3 of the epithelium. | |||
*Dyskeratotic cell common. | |||
Carcinoma in situ:<ref name=pmid24689850/> | |||
*"Full thickness" loss of stratification. | |||
**May have thin layer of compressed-appearing cells (3-5 cells thick) with their long axes parallel to the basement membrane. | |||
*[[Nuclear pleomorphism]] present. | |||
**Irregular nuclear contours. | |||
**Hyperchromasia. | |||
**Nucleoli increased in size and number. | |||
*Increase mitotic activity. | |||
**Atypical mitoses common. | |||
*Dyskeratotic/apoptotic cells typically very common. | |||
Negatives: | |||
*Basement membrane intact. | |||
**Smooth contour between epithelial layer and underlying stroma. | |||
*No [[stromal desmoplastic response]]. | |||
Subtypes: | |||
*Basal cell type. | |||
**Non-eosinophilic cytoplasm. | |||
**No apparent intercellular bridges (prickles). | |||
**Long axis of cells perpendicular to the basement membrane. | |||
**Typically non-keratinizing. | |||
*Spinous cell type. | |||
**Intercellular bridges (prickles) present. | |||
**Eosinophilic cytoplasm. | |||
**Typically keratinizing. | |||
===Images=== | ===Images=== | ||