48,475
edits
Difference between revisions of "Salivary glands"
Jump to navigation
Jump to search
more details in warthin
(→Overview: +IHC overview) |
(more details in warthin) |
||
| Line 1: | Line 1: | ||
The '''salivary glands''' help digest food. ENT surgeons take 'em out and want you to diagnose 'em. Cytopathology of the salivary glands is covered in the ''[[Head and neck cytopathology]]'' article. | The '''salivary glands''' help digest food. ENT surgeons take 'em out and want you to diagnose 'em. Cytopathology of the salivary glands is covered in the ''[[Head and neck cytopathology]]'' article. | ||
=Normal= | |||
==Types of salivary glands== | |||
Types of glands:<ref>[http://www.lab.anhb.uwa.edu.au/mb140/CorePages/Oral/oral.htm#LABSALIVA http://www.lab.anhb.uwa.edu.au/mb140/CorePages/Oral/oral.htm#LABSALIVA]</ref> | Types of glands:<ref>[http://www.lab.anhb.uwa.edu.au/mb140/CorePages/Oral/oral.htm#LABSALIVA http://www.lab.anhb.uwa.edu.au/mb140/CorePages/Oral/oral.htm#LABSALIVA]</ref> | ||
#Serrous - eosinophilic cytoplasmic granules, acinar arrangement - vaguely resembles the acinar morphology of the [[pancreas]]. | #Serrous - eosinophilic cytoplasmic granules, acinar arrangement - vaguely resembles the acinar morphology of the [[pancreas]]. | ||
#Mucinous - light eosinophilic staining. | #Mucinous - light eosinophilic staining. | ||
==Identifying the glands== | |||
The three main glands: | The three main glands: | ||
# Parotid: | # Parotid: | ||
| Line 31: | Line 31: | ||
*Sub'''m'''andibular = glands are '''m'''ixed. | *Sub'''m'''andibular = glands are '''m'''ixed. | ||
=Overview= | |||
==Benign tumours== | |||
'''Tabular form - adapted from Thompson<ref>{{Ref HaNP|295-319}}</ref>''' | '''Tabular form - adapted from Thompson<ref>{{Ref HaNP|295-319}}</ref>''' | ||
{| class="wikitable" | {| class="wikitable" | ||
| Line 97: | Line 97: | ||
|} | |} | ||
==Malignant tumours== | |||
'''Tabular form - adapted from Thompson<ref>{{Ref HaNP|325-357}}</ref>''' | '''Tabular form - adapted from Thompson<ref>{{Ref HaNP|325-357}}</ref>''' | ||
{| class="wikitable" | {| class="wikitable" | ||
| Line 156: | Line 156: | ||
|} | |} | ||
==DDx== | |||
Palate: | Palate: | ||
*Polymorphous low-grade adenocarcinoma. | *Polymorphous low-grade adenocarcinoma. | ||
| Line 162: | Line 162: | ||
*Pleomorphic adenoma. | *Pleomorphic adenoma. | ||
Parotid (benign): | |||
*Pleomorphic adenoma. | |||
*Warthin tumour. | |||
==IHC overview== | |||
General: | General: | ||
*Usually has limited value. | *Usually has limited value. | ||
| Line 262: | Line 266: | ||
==Papillary cystadeoma lymphomatosum== | ==Papillary cystadeoma lymphomatosum== | ||
*[[AKA]] '''Warthin tumour'''. | *[[AKA]] '''Warthin tumour'''. | ||
===General=== | ===General=== | ||
Epidemiology: | Epidemiology: | ||
*May be multicentric. | *May be multicentric ~ 15% of the time. | ||
* | *May be bilateral ~10% of the time. | ||
*Classically: male > female -- changing with more women smokers. | |||
*Smokers. | *Smokers. | ||
*Old - usu. 60s, very rarely < 40 years old. | |||
Notes: | Notes: | ||
| Line 283: | Line 288: | ||
* Papillae (nipple-shaped structures) with a two rows of pink (eosinophilic) epithelial cells (with cuboidal basal cells and columnar luminal cells) -- '''key feature'''. | * Papillae (nipple-shaped structures) with a two rows of pink (eosinophilic) epithelial cells (with cuboidal basal cells and columnar luminal cells) -- '''key feature'''. | ||
* Fibrous capsule - pink & homogenous on [[H&E stain]]. | * Fibrous capsule - pink & homogenous on [[H&E stain]]. | ||
* Cystic space. | * Cystic space filled with debris ''in situ'' (not necrosis). | ||
* Lymphoid stroma. | * Lymphoid stroma. | ||
| Line 406: | Line 411: | ||
===Microscopy=== | ===Microscopy=== | ||
Features: | |||
*Nests of cells, may from glands, single cells. (???) | *Nests of cells, may from glands, single cells. (???) | ||
| Line 415: | Line 421: | ||
*Sebaceous glands are serous glands and clear on H&E. | *Sebaceous glands are serous glands and clear on H&E. | ||
=See also= | |||
*[[Head and neck pathology]]. | *[[Head and neck pathology]]. | ||
*[[Thyroid gland]]. | *[[Thyroid gland]]. | ||
| Line 421: | Line 427: | ||
*[[Head and neck cytopathology]]. | *[[Head and neck cytopathology]]. | ||
=References= | |||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Head and neck pathology]] | [[Category:Head and neck pathology]] | ||