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Difference between revisions of "Salivary glands"
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==Mucocele== | ==Mucocele== | ||
===General=== | |||
*Benign. | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
* | *Ball of mucous. | ||
==Pleomorphic adenoma== | ==Pleomorphic adenoma== | ||
=== | ===General=== | ||
Features: | Features: | ||
*Very common - approx. 60% of parotid gland tumours.<ref name=Ref_HaNP295>{{Ref HaNP|295}}</ref> | *Very common - approx. 60% of parotid gland tumours.<ref name=Ref_HaNP295>{{Ref HaNP|295}}</ref> | ||
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**Other benign salivary gland tumours do not do this. | **Other benign salivary gland tumours do not do this. | ||
*Only benign childhood salivary gland tumour of significance. | *Only benign childhood salivary gland tumour of significance. | ||
===Gross=== | |||
*May be cartilaginous appearing. | |||
===Microscopic=== | ===Microscopic=== | ||
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*May be multifocal. | *May be multifocal. | ||
*Usu. parotid gland, occasionally submandibular gland. | *Usu. parotid gland, occasionally submandibular gland. | ||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Basophilic cells. | *Basophilic cells. | ||
*Usu. nests; may be | *Usu. nests; may be bilayered tubules ''or'' [[trabeculae]]. | ||
Notes: | Notes: | ||
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==Canalicular adenoma== | ==Canalicular adenoma== | ||
===General=== | |||
*Exclusively oral cavity. | |||
**80% of lesions on upper lip. | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Channels. | *Channels; "beading of cell". | ||
===IHC=== | |||
*p63 -ve. | |||
==Papillary cystadeoma lymphomatosum== | ==Papillary cystadeoma lymphomatosum== | ||
*AKA ''Warthin tumour''. | *[[AKA]] '''Warthin tumour'''. | ||
===General=== | |||
*Papillae. | *Papillae. | ||
Epidemiology: | |||
*May be multicentric. | |||
*Male > female. | |||
*Smokers. | |||
Notes: | |||
*No malignant transformation. | |||
*Not in submandibular gland. | |||
*Not in sublingual gland. | |||
*Not in children. | |||
===Gross=== | |||
*Motor-oil like fluid. | |||
*Cystic component larger in larger lesions. | |||
===Microscopy=== | ===Microscopy=== | ||
* Papillae (nipple-shaped structures) with a two rows of pink (eosinophilic) epithelial cells (with cuboidal basal cells and columnar luminal cells) -- '''key feature'''. | * Papillae (nipple-shaped structures) with a two rows of pink (eosinophilic) epithelial cells (with cuboidal basal cells and columnar luminal cells) -- '''key feature'''. | ||
* Fibrous capsule - pink & homogenous on H&E. | * Fibrous capsule - pink & homogenous on [[H&E stain]]. | ||
* Cystic space. | * Cystic space. | ||
* Lymphoid stroma. | * Lymphoid stroma. | ||
DDx: | |||
*Lymphoepithelial cyst. | *Lymphoepithelial cyst. | ||
**Cyst within a lymph node. | **Cyst within a lymph node. | ||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Papillary_cystadenoma_lymphomatosum3.jpg Warthin tumour - high mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Papillary_cystadenoma_lymphomatosum2.jpg Warthin tumour - intermed. mag. (WC)]. | |||
==Sebaceous adenoma== | ==Sebaceous adenoma== | ||
===Microscopic=== | |||
Features: | Features: | ||
*Benign counterpart of ''sebaceous carcinoma''. | *Benign counterpart of ''sebaceous carcinoma''. | ||
==Oncocytoma== | ==Oncocytoma== | ||
===General=== | |||
*No risk of malignant transformation. | |||
===Gross=== | |||
*Golden brown appearance. | |||
===Microscopic=== | |||
Features: | Features: | ||
*Like [[oncocytoma]]s elsewhere. | *Like [[oncocytoma]]s elsewhere. | ||
**Eosinophilic cytoplasm (H&E) | **Eosinophilic cytoplasm (on [[H&E stain]]). | ||
***Due to increased number of mitochrondria. | |||
**Fine capillaries. | |||
Notes: | |||
*May have clear cell change. | |||
*Multiple small incidental lesions = oncocytosis - ''not'' oncocytoma. | |||
===IHC=== | |||
*p63 +ve focally in nucleus. | |||
=Malignant= | =Malignant= | ||