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Difference between revisions of "Salivary glands"
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# Submandibular: | # Submandibular: | ||
#*Serous and mucinous glands. | #*Serous and mucinous glands. | ||
#**Serous ~90% of gland. | |||
#**Mucinous ~10% of gland. | |||
# Sublingual: | # Sublingual: | ||
#*Mucinous glands. | #*Mucinous glands. | ||
Other: | |||
*Adipose tissue is found between the glands. | |||
**It increases with age. | |||
Images: | Images: | ||
| Line 37: | Line 43: | ||
| '''DDx''' | | '''DDx''' | ||
| '''Other''' | | '''Other''' | ||
| '''Image''' | |||
|- | |- | ||
|Pleomorphic adenoma | |Pleomorphic adenoma | ||
| var. | |||
| '''mixed pop.'''; must include: (1) myoepithelium, (2) epithelium (ductal cells), (3) chondromyxoid stroma | |||
| var. | |||
| var. | |||
| (1) plasmacytoid | |||
| adenoid cystic c. | |||
| occ. encapsulated, <br>mixed pop. of glandular, <br>myoepithelial and mesenchymal cells | |||
| [http://en.wikipedia.org/wiki/File:Pleomorphic_adenoma_(1)_parotid_gland.jpg] | |||
|- | |- | ||
|Warthin tumour | |Warthin tumour | ||
| papillary, <br>'''bilayer''' | |||
| cuboid (basal), columnar (apical) | |||
| clearly seen | |||
| '''eosinophilic, abundant''' | |||
| unremarkable | |||
| sebaceous lymphadenoma | |||
| AKA ''papillary cystadenoma lymphomatosum'' | |||
| [http://en.wikipedia.org/wiki/File:Papillary_cystadenoma_lymphomatosum2.jpg], [http://commons.wikimedia.org/wiki/File:Papillary_cystadenoma_lymphomatosum3.jpg] | |||
|- | |- | ||
|Basal cell adenoma | |Basal cell adenoma | ||
| var., '''islands surrounded'''<br>'''by hyaline bands''' | |||
| basaloid | |||
| subtle | |||
| scant,<br>hyperchromatic | |||
| granular | |||
| basal cell adenoca | |||
| - | |||
| - | |||
|- | |- | ||
|Canalicular adenoma | |Canalicular adenoma | ||
| '''chains of cells''' | |||
| cuboid or columnar | |||
| subtle | |||
| scant,<br>hyperchromatic | |||
| granular | |||
| basal cell adenoma | |||
| IHC: p63- | |||
| - | |||
|- | |- | ||
|Sialoblastoma | |Sialoblastoma | ||
| var., '''islands surrounded'''<br>'''by loose fibrous stroma''' | |||
| basaloid | |||
| subtle | |||
| scant, hyperch. | |||
| granular | |||
| basal cell adenoca | |||
| - | |||
| - | |||
|- | |- | ||
|} | |} | ||
| Line 69: | Line 116: | ||
| nuclei sm. | | nuclei sm. | ||
| ? | | ? | ||
| | | IHC: p63+ | ||
|- | |- | ||
|Acinic cell adenocarcinoma (AcCC) | |Acinic cell adenocarcinoma (AcCC) | ||
| Line 105: | Line 152: | ||
| ovoid & small with<br>small nucleoli | | ovoid & small with<br>small nucleoli | ||
| ? | | ? | ||
| minor salivary gland tumour,<br>often in palate,<br> cytologically monotonous | | minor salivary gland tumour,<br>often in palate,<br> cytologically monotonous; IHC: S100+, CK+, vim.+, GFAP+/-, BCL2+/- | ||
|- | |- | ||
|} | |} | ||
| Line 156: | Line 203: | ||
==Basal cell adenoma== | ==Basal cell adenoma== | ||
===General=== | |||
*~2% of salivary gland tumours. | |||
*May be multifocal. | |||
*Usu. parotid gland, occasionally submandibular gland. | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Basophilic cells. | *Basophilic cells. | ||
* | *Usu. nests; may be bilayed tubules ''or'' trabeculae. | ||
Notes: | |||
*No chondromyxoid stroma. | |||
**Chondromyxoid stroma present -> pleomorphic adenoma. | |||
*Neoplastic cells embeded in stroma ("stromal invasion") = basal cell adenocarcinoma. | |||
**Basal cell adenocarcinoma may be cytologically indistinguishable from basal cell adenoma, i.e. "bad" architecture makes it a basal cell adenocarcinoma. | |||
===IHC=== | |||
*Luminal stains +ve: CK7 +ve, CAM5.2 +ve. | |||
==Canalicular adenoma== | ==Canalicular adenoma== | ||