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Low-grade fibromyxoid sarcoma (view source)
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'''Low-grade_fibromyxoid_sarcoma''', abbreviated '''LGFMS''', is an uncommon [[malignant]] [[Fibroblastic/myofibroblastic tumours|fibroblastic/myofibroblastic tumour]]. | |||
It is also known as '''hyalinizing spindle cell tumour'''. It should '''not''' be confused with ''[[myxofibrosarcoma]]''. | |||
==General== | |||
*Deep soft tissue. | |||
*Related to ''hyalinizing spindle cell tumour with giant collagen rosettes''.<ref name=pmid20864787>{{Cite journal | last1 = Ramaswamy | first1 = AS. | last2 = Chatura | first2 = KR. | title = Hyalinizing spindle cell tumor with giant rosettes. | journal = Ann Saudi Med | volume = 31 | issue = 1 | pages = 83-6 | month = | year = | doi = | PMID = 20864787 | PMC = 3101732 }}</ref> | |||
==Microscopic== | |||
Features:<ref>{{cite journal |author=Vernon SE, Bejarano PA |title=Low-grade fibromyxoid sarcoma: a brief review |journal=Arch. Pathol. Lab. Med. |volume=130 |issue=9 |pages=1358–60 |year=2006 |month=September |pmid=16948525 |doi= |url=}}</ref> | |||
*[[Myxoid stroma]] alternating with fibrogenic areas - '''key feature'''. | |||
*Low cellularity. | |||
*Spindle cells. | |||
*+/-Rosette of collagen with central hyaline core.<ref name=Ref_WMSP611>{{Ref WMSP|611}}</ref> | |||
Notes: | |||
*Few/absent mitoses. | |||
DDx: | |||
*[[Leiomyoma]]. | |||
*[[Myxoid liposarcoma]]. | |||
*[[Desmoplastic fibroblastoma]]. | |||
*[[Intramuscular myxoma]]. | |||
===Images=== | |||
<gallery> | |||
Image:Low-grade_fibromyxoid_sarcoma_-_low_mag.jpg | LGFMS - low mag. (WC) | |||
Image:Low-grade_fibromyxoid_sarcoma_-_intermed_mag.jpg | LGFMS - intermed. mag. (WC) | |||
Image:Low-grade_fibromyxoid_sarcoma_-2-_high_mag.jpg | LGFMS - high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://www.springerimages.com/Images/MedicineAndPublicHealth/1-10.1007_s00428-009-0776-0-7 LGFMS (springerimages.com)]. | |||
*[http://www.uscap.org/site~/iap2006/slides18-2v.htm LGFMS (uscap.org)]. | |||
==IHC== | |||
Features:<ref name=Ref_WMSP611>{{Ref WMSP|611}}</ref> | |||
*EMA +ve. | |||
*CD99 +ve. | |||
*BCL2 +ve. | |||
Others:<ref name=Ref_WMSP611>{{Ref WMSP|611}}</ref> | |||
*SMA -ve. | |||
*S100 -ve. | |||
*Desmin -ve. | |||
==Molecular pathology== | |||
*t(7;16)(q33;p11).<ref>{{cite journal |author=Panagopoulos I, Storlazzi CT, Fletcher CD, ''et al.'' |title=The chimeric FUS/CREB3l2 gene is specific for low-grade fibromyxoid sarcoma |journal=Genes Chromosomes Cancer |volume=40 |issue=3 |pages=218–28 |year=2004 |month=July |pmid=15139001 |doi=10.1002/gcc.20037 |url=}}</ref> | |||
*t(11;16).<ref name=Ref_WMSP611>{{Ref WMSP|611}}</ref> | |||
==See also== | |||
*[[Fibroblastic/myofibroblastic tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Fibroblastic/myofibroblastic tumours]] | |||