Difference between revisions of "Mixed germ cell tumour"

Mixed germ cell tumour (view source)

188 bytes added , 06:30, 15 November 2014

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 ==IHC==
+*Immunostains are useful for differentiating components, e.g. yolk sac tumour versus [[embryonal carcinoma]].
+Looking for elements
 *Beta-hCG +ve - if syncytiotrophoblasts are present.
-*AFP +ve - a yolk sac tumour component is present.
+*AFP +ve (or Glypican 3 +ve) - a yolk sac tumour component is present.
 *GFAP +ve - if neuroepithelium is present.
 A panel:
-*PLAP.
 *CD30 +ve -- [[embryonal carcinoma]].
-*CD117 +ve -- [[seminoma]].
+*OCT4 +ve -- [[seminoma]].
 *D2-40 +ve -- seminoma, useful for [[LVI]].
 *Pankeratin +ve -- embryonal carcinoma.
@@ Line 84: / Line 86: @@
 *EMA +ve -- metastatic carcinoma.<ref>{{Cite journal  | last1 = Shek | first1 = TW. | last2 = Yuen | first2 = ST. | last3 = Luk | first3 = IS. | last4 = Wong | first4 = MP. | title = Germ cell tumour as a diagnostic pitfall of metastatic carcinoma. | journal = J Clin Pathol | volume = 49 | issue = 3 | pages = 223-5 | month = Mar | year = 1996 | doi =  | PMID = 8675733 }}</ref>
 *Vimentin.
-*AFP +ve -- [[yolk sac tumour]].
+*Glypican 3 +ve -- [[yolk sac tumour]].
-*A1A +ve -- yolk sac tumour.
+**Others: A1A +ve -- yolk sac tumour, AFP +ve -- yolk sac tumour.
 ==Sign out==