Difference between revisions of "Neuropathology"

Neuropathology (view source)

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 ==Multiple sclerosis==
-*Abbreviated ''MS''.
+:Abbreviated '''MS'''.
-===General===
+{{Main|Multiple sclerosis}}
-*A bread 'n butter disease of neurology in Canada.
-Clinical:
-*CSF: oligoclonal bands of immunoglobulin.<ref>{{Ref PBoD8|1311}}</ref>
-Classification of MS lesions:
-*Early active.
-*Inactive.
-*Early remyelinating.
-*Late remyelinating.
-===Radiologic/Gross===
-Features:<ref>URL: [http://library.med.utah.edu/kw/ms/path.html http://library.med.utah.edu/kw/ms/path.html]. Accessed on: 12 July 2010.</ref>
-*White matter lesions.
-**Cerebrum (classically): periventricular distribution.
-**Optic nerves (optic neuritis) - classic presentation.
-===Microscopic===
-Features:<ref>URL: [http://library.med.utah.edu/kw/ms/path.html http://library.med.utah.edu/kw/ms/path.html]. Accessed on: 12 July 2010.</ref>
-*Perivascular inflammation.
-**Esp. lymphocytes.
-*Demyelination.
-**Subcortical myelinated fibers are often spared.
-Chronic lesions - specific features:<ref>{{Ref APBR|425 Q43}}</ref>
-#Macrophages.
-#Astrocyte enlargement.
-DDx:
-*[[ADEM]].
-*[[Neuromyelitis optica]].
-*[[Lymphoma]].
-*[[Diffuse astrocytoma]].
-Images:
-*[http://path.upmc.edu/cases/case79.html Multiple sclerosis masquerading as a diffuse astrocytoma - several images (upmc.edu)].
-*[http://path.upmc.edu/cases/case636.html Tumefactive multiple sclerosis - several images (upmc.edu)].
-===IHC===
-*HAM-56 - macrophages.
-*CD8 - lymphocytes.
 ==Cerebral amyloid angiopathy==