Difference between revisions of "Clear cell carcinoma of the uterine cervix"

Clear cell carcinoma of the uterine cervix (view source)

41 bytes removed , 20:14, 12 November 2014

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 ==Microscopic==
 Features:<ref name=pmid22885379/>
-*Like [[clear cell carcinoma]] elsewhere:
+*Clear cytoplasm - '''key feature'''.
-**Clear cytoplasm - '''key feature'''.
+**May be focal/absent!
-***May be absent!
 **Cells have large free/luminal surface area (hobnailing pattern) and small non-free surface.
-**Moderate-to-severe [[nuclear pleomorphism]].
+*Moderate-to-severe [[nuclear pleomorphism]].
-**Tubular and/or cystic morphology.
+*Tubular and/or cystic morphology.
-***May be (simple) papillary and/or solid.
+**May be (simple) papillary and/or solid.
 *Adenosis - typically adjacent.
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 *[[Clear cell carcinoma of the endometrium]] - diagnosis based on clinico-radiologic correlation (IHC & histology not useful).<ref name=pmid22885379>{{Cite journal  | last1 = Offman | first1 = SL. | last2 = Longacre | first2 = TA. | title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). | journal = Adv Anat Pathol | volume = 19 | issue = 5 | pages = 296-312 | month = Sep | year = 2012 | doi = 10.1097/PAP.0b013e31826663b1 | PMID = 22885379 }}</ref>
 *[[Serous carcinoma of the endometrium]].
-*[[Serous carcinoma of the uterine cervix]].
+*[[Serous carcinoma]] of the uterine cervix.
 *[[Mesonephric adenocarcinoma]].