Difference between revisions of "Urothelial carcinoma"

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Urothelial carcinoma (view source)

Revision as of 16:53, 11 November 2014

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→‎Plasmacytoid urothelial cell carcinoma: split out
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====Plasmacytoid urothelial cell carcinoma====
====Plasmacytoid urothelial cell carcinoma====
General:<ref name=pmid24943778>{{Cite journal  | last1 = Qin | first1 = M. | last2 = Wang | first2 = G. | last3 = Sun | first3 = Y. | last4 = He | first4 = Q. | title = Plasmacytoid urothelial carcinoma of the bladder. | journal = Indian J Pathol Microbiol | volume = 57 | issue = 2 | pages = 320-2 | month =  | year =  | doi = 10.4103/0377-4929.134730 | PMID = 24943778 }}</ref>
{{Main|Plasmacytoid urothelial carcinoma}}
*Aggresive.
*Uncommon.
*Often associated with positive margins (relative to other UCC variants); spreads along fascial planes.<ref name=pmid24582117>{{Cite journal  | last1 = Kaimakliotis | first1 = HZ. | last2 = Monn | first2 = MF. | last3 = Cheng | first3 = L. | last4 = Masterson | first4 = TA. | last5 = Cary | first5 = KC. | last6 = Pedrosa | first6 = JA. | last7 = Foster | first7 = RS. | last8 = Koch | first8 = MO. | last9 = Bihrle | first9 = R. | title = Plasmacytoid bladder cancer: variant histology with aggressive behavior and a new mode of invasion along fascial planes. | journal = Urology | volume = 83 | issue = 5 | pages = 1112-6 | month = May | year = 2014 | doi = 10.1016/j.urology.2013.12.035 | PMID = 24582117 }}</ref>
 
Features:
*Plasmacytoid morphology:
**Abundant gray cytoplasm.
**Eccentric nucleus - usually round, occasionally crescentic.
*+/-Mucous (common).
 
Images:
*[http://path.upmc.edu/cases/case267.html Plasmacytoid UCC - several images (upmc.edu)].
 
IHC:<ref name=pmid24246859>{{Cite journal  | last1 = Zhang | first1 = W. | last2 = Jiang | first2 = YX. | last3 = Liu | first3 = Y. | last4 = Yu | first4 = WJ. | last5 = Zhao | first5 = H. | last6 = Li | first6 = YJ. | title = [Plasmacytoid urothelial carcinoma of the urinary bladder: a clinicopathologic study of 16 cases]. | journal = Zhonghua Bing Li Xue Za Zhi | volume = 42 | issue = 7 | pages = 433-7 | month = Jul | year = 2013 | doi =  | PMID = 24246859 }}</ref>
*AE1/AE3 +ve (16 +ve/16 cases).
*EMA +ve (16 +ve/16 cases).
*CK7 +ve (16 +ve/16 cases).
*CK20 +ve (16 +ve/16 cases).
*CD138 (15 +ve/16 cases).
*p63 (11 +ve/16 cases).


====Nested urothelial cell carcinoma====
====Nested urothelial cell carcinoma====
Michael
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