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Juxtaglomerular cell tumour (view source)
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'''Juxtaglomerular cell tumour''', abbreviated '''JCT''', is a rare [[kidney tumour]]. | |||
==General== | |||
*Rare. | |||
*Etiology: increased renin. | |||
Clinical:<ref name=pmid18192852>{{Cite journal | last1 = Wong | first1 = L. | last2 = Hsu | first2 = TH. | last3 = Perlroth | first3 = MG. | last4 = Hofmann | first4 = LV. | last5 = Haynes | first5 = CM. | last6 = Katznelson | first6 = L. | title = Reninoma: case report and literature review. | journal = J Hypertens | volume = 26 | issue = 2 | pages = 368-73 | month = Feb | year = 2008 | doi = 10.1097/HJH.0b013e3282f283f3 | PMID = 18192852 }}</ref> | |||
*[[Hypertension]]. | |||
*Increased aldosterone. | |||
**Causes hypokalemia. | |||
*Increased plasma renin. | |||
==Microscopic== | |||
Features:<ref name=pmid21191395/> | |||
*Polygonal cells. | |||
*Abundant granular, eosinophilic cytoplasm.<ref name=pmid436071/> | |||
*Perinuclear halo. | |||
DDx: | |||
*[[Chromophobe renal cell carcinoma]], eosinophilic variant. | |||
Image: | |||
*[http://www.nature.com/ki/journal/v79/n2/fig_tab/ki2010445f1.html#figure-title Reninoma (nature.com)].<ref name=pmid21191395/> | |||
==Stains== | |||
Cytoplasmic granules.<ref name=pmid436071>{{Cite journal | last1 = Hanna | first1 = W. | last2 = Tepperman | first2 = B. | last3 = Logan | first3 = AG. | last4 = Robinette | first4 = MA. | last5 = Colapinto | first5 = R. | last6 = Phillips | first6 = MJ. | title = Juxtaglomerular cell tumour (reninoma) with paroxysmal hypertension. | journal = Can Med Assoc J | volume = 120 | issue = 8 | pages = 957-9 | month = Apr | year = 1979 | doi = | PMID = 436071 PMC = 1819229 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819229/?tool=pubmed }}</ref> | |||
*PAS +ve. | |||
*PASD +ve. | |||
==IHC== | |||
Features:<ref name=pmid21191395>{{Cite journal | last1 = Chao | first1 = CT. | last2 = Chang | first2 = FC. | last3 = Wu | first3 = VC. | last4 = Chen | first4 = JC. | title = Reninoma. | journal = Kidney Int | volume = 79 | issue = 2 | pages = 260 | month = Jan | year = 2011 | doi = 10.1038/ki.2010.445 | PMID = 21191395 }}</ref> | |||
*Actin +ve. | |||
*Cytokeratin -ve. | |||
*HMB-45 -ve. | |||
==EM== | |||
Features: | |||
*Vesicles - contain renin.<ref name=upmc29>URL: [http://path.upmc.edu/cases/case29/micro.html http://path.upmc.edu/cases/case29/micro.html]. Accessed on: 18 December 2011.</ref> | |||
==See also== | |||
*[[Kidney tumours]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Kidney tumours]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||