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Difference between revisions of "Prostate-specific antigen"
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Prostate-specific antigen (view source)
Revision as of 06:35, 2 November 2014
, 06:35, 2 November 2014no edit summary
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[[Image: | [[Image:Advanced prostate carcinoma - PSA - 2 -- very high mag.jpg|thumb|200px|[[Micrograph]] showing a PSA immunostain marking [[prostate carcinoma]].]] | ||
'''Prostate specific antigen''', abbreviated '''PSA''', is marker that is quite [[specificity|specific]] for the prostate. | '''Prostate specific antigen''', abbreviated '''PSA''', is marker that is quite [[specificity|specific]] for the prostate. | ||
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*Increases with age.<ref name=pmid12350489>{{cite journal |author=Ku JH, Ahn JO, Lee CH, ''et al.'' |title=Distribution of serum prostate-specific antigen in healthy Korean men: influence of ethnicity |journal=Urology |volume=60 |issue=3 |pages=475–9 |year=2002 |month=September |pmid=12350489 |doi= |url=}}</ref> | *Increases with age.<ref name=pmid12350489>{{cite journal |author=Ku JH, Ahn JO, Lee CH, ''et al.'' |title=Distribution of serum prostate-specific antigen in healthy Korean men: influence of ethnicity |journal=Urology |volume=60 |issue=3 |pages=475–9 |year=2002 |month=September |pmid=12350489 |doi= |url=}}</ref> | ||
===Prostate specific antigen density=== | ====Prostate specific antigen density==== | ||
:Abbreviated ''PSAD''. | :Abbreviated ''PSAD''. | ||
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*Benign prostate gland versus [[prostate cancer]].<ref name=pmid1371554>{{cite journal |author=Benson MC, Whang IS, Pantuck A, ''et al.'' |title=Prostate specific antigen density: a means of distinguishing benign prostatic hypertrophy and prostate cancer |journal=J. Urol. |volume=147 |issue=3 Pt 2 |pages=815–6 |year=1992 |month=March |pmid=1371554 |doi= |url=}}</ref><ref>{{cite journal |author=Verma A, St Onge J, Dhillon K, Chorneyko A |title=PSA density improves prediction of prostate cancer |journal=Can J Urol |volume=21 |issue=3 |pages=7312–21 |year=2014 |month=June |pmid=24978363 |doi= |url=}}</ref> | *Benign prostate gland versus [[prostate cancer]].<ref name=pmid1371554>{{cite journal |author=Benson MC, Whang IS, Pantuck A, ''et al.'' |title=Prostate specific antigen density: a means of distinguishing benign prostatic hypertrophy and prostate cancer |journal=J. Urol. |volume=147 |issue=3 Pt 2 |pages=815–6 |year=1992 |month=March |pmid=1371554 |doi= |url=}}</ref><ref>{{cite journal |author=Verma A, St Onge J, Dhillon K, Chorneyko A |title=PSA density improves prediction of prostate cancer |journal=Can J Urol |volume=21 |issue=3 |pages=7312–21 |year=2014 |month=June |pmid=24978363 |doi= |url=}}</ref> | ||
====A forumla for PSAD==== | =====A forumla for PSAD===== | ||
Benson ''et al.'':<ref name=pmid1371554>{{cite journal |author=Benson MC, Whang IS, Pantuck A, ''et al.'' |title=Prostate specific antigen density: a means of distinguishing benign prostatic hypertrophy and prostate cancer |journal=J. Urol. |volume=147 |issue=3 Pt 2 |pages=815–6 |year=1992 |month=March |pmid=1371554 |doi= |url=}}</ref> | Benson ''et al.'':<ref name=pmid1371554>{{cite journal |author=Benson MC, Whang IS, Pantuck A, ''et al.'' |title=Prostate specific antigen density: a means of distinguishing benign prostatic hypertrophy and prostate cancer |journal=J. Urol. |volume=147 |issue=3 Pt 2 |pages=815–6 |year=1992 |month=March |pmid=1371554 |doi= |url=}}</ref> | ||
:<math>PASD = \frac{serum PSA}{volume}</math> | :<math>PASD = \frac{serum PSA}{volume}</math> | ||
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*The volume of an ellipsoid is: | *The volume of an ellipsoid is: | ||
::<math>\frac{4}{3}\pi D1 \times D1 \times D3</math>. | ::<math>\frac{4}{3}\pi D1 \times D1 \times D3</math>. | ||
===Immunostain=== | |||
*Specific for prostate. | |||
==Microscopic== | |||
Features: | |||
*Granular cytoplasmic staining. | |||
Notes: | |||
*May be very weak -- need to look at high power. | |||
<gallery> | |||
Image: Advanced prostate carcinoma - PSA -- high mag.jpg | Adv Pca - PSA - high mag. (WC) | |||
Image: Advanced prostate carcinoma - PSA -- very high mag.jpg | Adv Pca - PSA - very high mag. (WC) | |||
Image: Advanced prostate carcinoma - PSA - 2 -- high mag.jpg | Adv Pca - PSA - high mag. (WC) | |||
Image: Advanced prostate carcinoma - PSA - 2 -- very high mag.jpg | Adv Pca - PSA - very high mag. (WC) | |||
</gallery> | |||
==See also== | ==See also== | ||