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Difference between revisions of "Heart transplant pathology"
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Heart transplant pathology (view source)
Revision as of 20:25, 7 January 2011
, 20:25, 7 January 2011+table - overview
(+table - overview) |
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*Cellular rejection. | *Cellular rejection. | ||
*Chronic rejection. | *Chronic rejection. | ||
==Overview - table== | |||
Grading scheme 2004/1990:<ref>{{Ref WMSP|136}}</ref> | |||
{| class="wikitable" | |||
| Type (grade) | |||
| Description | |||
| Details | |||
| Image | |||
|- | |||
| acute | |||
| edema, dilated small vessels | |||
| scant inflammation | |||
| [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970592-7&figureId=fig4] | |||
|- | |||
| cellular (0R) | |||
| normal | |||
| no extravascular monocytes | |||
| | |||
|- | |||
| cellular (1R) | |||
| infiltrate, myocyte damage | |||
| scant interstitial infiltrate (lymphoplasmic), scant damage | |||
| [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970592-7&figureId=fig1 mild] | |||
|- | |||
| cellular (2R) | |||
| space-occupying lesion | |||
| diffuse interstitial infiltrate displaces parenchyma (lymphoplasmic), obvious damage | |||
| [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970592-7&figureId=fig2 mod.], [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970592-7&figureId=fig3 mod. resolving] | |||
|- | |||
| cellular (3R) | |||
| disruption of normal arch. | |||
| diffuse interstitial infiltrate disrupts parenchyma (lymphoplasmic & PMNs), fibre loss/damage | |||
| | |||
|- | |||
| chronic | |||
| concentric intimal thicking | |||
| internal elastic lamina preserved (unlike atherosclerosis) | |||
| [http://newsroom.ucla.edu/portal/ucla/srp-view.aspx?id=118724], [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970592-7&figureId=fig5] | |||
|} | |||
==Biopsy site reaction== | ==Biopsy site reaction== | ||