Difference between revisions of "Medical liver disease"

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Medical liver disease (view source)

Revision as of 02:37, 26 October 2014

1,916 bytes removed ,  02:37, 26 October 2014
→‎Alpha-1 antitrypsin deficiency: split out into separate article
(→‎Alpha-1 antitrypsin deficiency: split out into separate article)
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==Alpha-1 antitrypsin deficiency==
==Alpha-1 antitrypsin deficiency==
*[[AKA]] ''alpha1-antiprotease inhibitor deficiency''.
*[[AKA]] ''alpha1-antiprotease inhibitor deficiency''.
===General===
{{Main|Alpha-1 antitrypsin deficiency }}
Etiology:
*Genetic defect.
**Prevalence 1 in 2000-5000.<ref name=pmid21960536>{{Cite journal  | last1 = Stoller | first1 = JK. | last2 = Aboussouan | first2 = LS. | title = A Review of Alpha-1 Antitrypsin Deficiency. | journal = Am J Respir Crit Care Med | volume =  | issue =  | pages =  | month = Sep | year = 2011 | doi = 10.1164/rccm.201108-1428CI | PMID = 21960536 }}
</ref>
 
Causes:
*Lung and liver injury.
**Lung -> panlobular [[emphysema]].
 
===Microscopic===
Features:
*Pink globules in zone 1 (periportal).
**Globules ''not'' seen in children.
**May ''not'' be present in late stage (cirrhotic).
**Best seen on [[PASD stain]].
**Can be seen on H&E -- if one looks carefully.
 
Note:
*The pink globules may be seen in the context of cirrhosis; cases should be confirmation with IHC.
 
===Images===
<gallery>
Image:Alpha-1 antitrypsin deficiency.PAS Diastase.jpg | Alpha-1 AT deficiency - PASD. (WC/JMGardner)
</gallery>
www:
*[http://moon.ouhsc.edu/kfung/jty1/opaq/pathquiz/l1k001-pq01.htm Alpha-1 AT (ouhsc.edu)].
*[http://www.pathpedia.com/Education/eAtlas/Histopathology/Liver_and_bile_ducts/Alpha-1_antitrypsin_deficiency.aspx Alpha-1 AT (pathpedia.com)].
 
===Stains===
*PAS +ve.<ref name=pmid6189389>{{Cite journal  | last1 = Qizilbash | first1 = A. | last2 = Young-Pong | first2 = O. | title = Alpha 1 antitrypsin liver disease differential diagnosis of PAS-positive, diastase-resistant globules in liver cells. | journal = Am J Clin Pathol | volume = 79 | issue = 6 | pages = 697-702 | month = Jun | year = 1983 | doi =  | PMID = 6189389 }}</ref>
*PASD +ve.<ref name=pmid6189389/>
 
===IHC===
*A1-AT +ve globules.<Ref name=pmid3512609>{{Cite journal  | last1 = Theaker | first1 = JM. | last2 = Fleming | first2 = KA. | title = Alpha-1-antitrypsin and the liver: a routine immunohistological screen. | journal = J Clin Pathol | volume = 39 | issue = 1 | pages = 58-62 | month = Jan | year = 1986 | doi =  | PMID = 3512609 }}</ref>


=Other=
=Other=
Michael
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