Difference between revisions of "Pancreas"

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Pancreas (view source)

Revision as of 05:02, 21 October 2014

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→‎Acinar cell carcinoma of the pancreas: split out
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*[[AKA]] ''acinar cell carcinoma''.
*[[AKA]] ''acinar cell carcinoma''.
*[[AKA]] ''pancreatic acinar cell carcinoma''.<ref name=pmid>{{Cite journal  | last1 = Thomas | first1 = PC. | last2 = Nash | first2 = GF. | last3 = Aldridge | first3 = MC. | title = Pancreatic acinar cell carcinoma presenting as acute pancreatitis. | journal = HPB (Oxford) | volume = 5 | issue = 2 | pages = 111-3 | month =  | year = 2003 | doi = 10.1080/13651820310001153 | PMID = 18332967 }}</ref>
*[[AKA]] ''pancreatic acinar cell carcinoma''.<ref name=pmid>{{Cite journal  | last1 = Thomas | first1 = PC. | last2 = Nash | first2 = GF. | last3 = Aldridge | first3 = MC. | title = Pancreatic acinar cell carcinoma presenting as acute pancreatitis. | journal = HPB (Oxford) | volume = 5 | issue = 2 | pages = 111-3 | month =  | year = 2003 | doi = 10.1080/13651820310001153 | PMID = 18332967 }}</ref>
 
{{Main|Acinar cell carcinoma of the pancreas}}
===General===
*Rare.
*Solid epithelial exocrine tumour.<ref>URL: [http://brighamrad.harvard.edu/Cases/bwh/hcache/380/full.html http://brighamrad.harvard.edu/Cases/bwh/hcache/380/full.html]. Accessed on: 15 January 2012.</ref>
*Poor prognosis; mean survival of 18 months in one series.<ref name=pmid1384374/>
 
Clinical:<ref name=pmid1384374>{{Cite journal  | last1 = Klimstra | first1 = DS. | last2 = Heffess | first2 = CS. | last3 = Oertel | first3 = JE. | last4 = Rosai | first4 = J. | title = Acinar cell carcinoma of the pancreas. A clinicopathologic study of 28 cases. | journal = Am J Surg Pathol | volume = 16 | issue = 9 | pages = 815-37 | month = Sep | year = 1992 | doi =  | PMID = 1384374 }}</ref>
*Increased serum lipase.
**Associated with arthralgias (joint pain).
*Classic presentation - Schmid triad:<ref name=pmid20168061>{{Cite journal  | last1 = Jang | first1 = SH. | last2 = Choi | first2 = SY. | last3 = Min | first3 = JH. | last4 = Kim | first4 = TW. | last5 = Lee | first5 = JA. | last6 = Byun | first6 = SJ. | last7 = Lee | first7 = JW. | title = [A case of acinar cell carcinoma of pancreas, manifested by subcutaneous nodule as initial clinical symptom]. | journal = Korean J Gastroenterol | volume = 55 | issue = 2 | pages = 139-43 | month = Feb | year = 2010 | doi =  | PMID = 20168061 }}</ref>
*#Subcutaneous [[fat necrosis]].
*#Polyarthritis.
*#Eosinophilia.
 
===Gross===
*Usually head of pancreas.
 
===Microscopic===
Features:<ref name=pmid1384374/>
*Cells reminiscent of pancreatic acinus cells:
**Granular, basophilic cytoplasm - usu. abundant.
**Round/oval nucleus.
***Nucleolus prominent.
*Architecture:
**Nests, sheets, trabecular, glandular.
 
DDx:
*[[Pancreatic neuroendocrine tumour]].
*[[Invasive ductal carcinoma of the pancreas]].
 
====Images====
<gallery>
Image:Acinar_cell_carcinoma_of_the_pancreas_-_high_mag.jpg | Pancreatic acinar cell carcinoma - high mag. (WC/Nephron)
Image:Acinar_cell_carcinoma_of_the_pancreas_-_very_high_mag.jpg | Pancreatic acinar cell carcinoma - very high mag. (WC/Nephron)
</gallery>
www:
*[http://path.upmc.edu/cases/case377.html Acinar cell carcinoma - several images (upmc.edu)].
*[http://brighamrad.harvard.edu/Cases/bwh/hcache/380/full.html Acinar cell carcinoma - several images (harvard.edu)].
*[http://www.nature.com/modpathol/journal/v20/n1s/fig_tab/3800686f12.html#figure-title Acinar cell carcinoma - 1 (nature.com)].
*[http://www.nature.com/modpathol/journal/v20/n1s/fig_tab/3800686f13.html#figure-title Acinar cell carcinoma - 2 (nature.com)].<ref name=pmid17486055>{{Cite journal  | last1 = Klimstra | first1 = DS. | title = Nonductal neoplasms of the pancreas. | journal = Mod Pathol | volume = 20 Suppl 1 | issue =  | pages = S94-112 | month = Feb | year = 2007 | doi = 10.1038/modpathol.3800686 | PMID = 17486055 }}</ref>
===Stains===
Features:<ref name=pmid1384374/>
*PAS +ve (granular).
*PASD +ve.
 
===IHC===
*Trypsin +ve -- '''key stain'''.
*Lipase +ve.
*Chromogranin +ve (scattered, focal).
*CD56 -ve. (?)


==Pancreatoblastoma==
==Pancreatoblastoma==
Michael
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