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Difference between revisions of "Peripheral nerve sheath tumours"
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Peripheral nerve sheath tumours (view source)
Revision as of 04:12, 7 January 2011
, 04:12, 7 January 2011→Malignant peripheral nerve sheath tumours
| Line 106: | Line 106: | ||
Features: | Features: | ||
*Cellular. | *Cellular. | ||
*Nuclear atypia. | |||
*Mitoses. | *Mitoses. | ||
| Line 117: | Line 118: | ||
Notes: | Notes: | ||
*May be diagnosed in a poorly diff. tumour if patient has NF1. | *May be diagnosed in a poorly diff. tumour if patient has NF1. | ||
====Grading==== | |||
*Can be graded histologically,<ref name=pmid14508395>{{cite journal |author=Zhou H, Coffin CM, Perkins SL, Tripp SR, Liew M, Viskochil DH |title=Malignant peripheral nerve sheath tumor: a comparison of grade, immunophenotype, and cell cycle/growth activation marker expression in sporadic and neurofibromatosis 1-related lesions |journal=Am. J. Surg. Pathol. |volume=27 |issue=10 |pages=1337–45 |year=2003 |month=October |pmid=14508395 |doi= |url=}}</ref> and this is prognostic.<ref name=pmid16923196>{{cite journal |author=Kar M, Deo SV, Shukla NK, ''et al.'' |title=Malignant peripheral nerve sheath tumors (MPNST)--clinicopathological study and treatment outcome of twenty-four cases |journal=World J Surg Oncol |volume=4 |issue= |pages=55 |year=2006 |pmid=16923196 |pmc=1560134 |doi=10.1186/1477-7819-4-55 |url=}}</ref> | |||
Sarcoma grading system<ref name=pmid6693192>{{cite journal |author=Trojani M, Contesso G, Coindre JM, ''et al.'' |title=Soft-tissue sarcomas of adults; study of pathological prognostic variables and definition of a histopathological grading system |journal=Int. J. Cancer |volume=33 |issue=1 |pages=37–42 |year=1984 |month=January |pmid=6693192 |doi= |url=}}</ref> - based on: | |||
*Tumour differentiation. | |||
*Mitotic rate. | |||
*Necrosis. | |||
===IHC=== | ===IHC=== | ||
| Line 122: | Line 131: | ||
*S-100 +ve ~ 30% of tumours. | *S-100 +ve ~ 30% of tumours. | ||
*SOX10 +ve ~ 50% of tumours. | *SOX10 +ve ~ 50% of tumours. | ||
Others:<ref name=pmid14508395>{{cite journal |author=Zhou H, Coffin CM, Perkins SL, Tripp SR, Liew M, Viskochil DH |title=Malignant peripheral nerve sheath tumor: a comparison of grade, immunophenotype, and cell cycle/growth activation marker expression in sporadic and neurofibromatosis 1-related lesions |journal=Am. J. Surg. Pathol. |volume=27 |issue=10 |pages=1337–45 |year=2003 |month=October |pmid=14508395 |doi= |url=}}</ref> | |||
*p53. | |||
*p16. | |||
*p27. | |||
*MIB-1. | |||
==See also== | ==See also== | ||