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Difference between revisions of "Bizarre parosteal osteochondromatous proliferation"
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Bizarre parosteal osteochondromatous proliferation (view source)
Revision as of 15:06, 17 October 2014
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| Synonyms =Nora lesion | | Synonyms = Nora lesion | ||
| Micro = | | Micro = | ||
| Subtypes = | | Subtypes = | ||
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| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = | | Site = hands, feet | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
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| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = | | Prevalence = rare | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
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| Tx = | | Tx = | ||
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'''Bizarre parosteal osteochondromatous proliferation''', also '''Nora lesion''', is a distinctive rare lesion of the hand or foot.<ref name=pmid19057740>{{Cite journal | last1 = Gruber | first1 = G. | last2 = Giessauf | first2 = C. | last3 = Leithner | first3 = A. | last4 = Zacherl | first4 = M. | last5 = Clar | first5 = H. | last6 = Bodo | first6 = K. | last7 = Windhager | first7 = R. | title = Bizarre parosteal osteochondromatous proliferation (Nora lesion): a report of 3 cases and a review of the literature. | journal = Can J Surg | volume = 51 | issue = 6 | pages = 486-9 | month = Dec | year = 2008 | doi = | PMID = 19057740 }}</ref> | |||
==General== | ==General== | ||
A distinctive osteochondromatous proliferation of hands and feet. | A distinctive osteochondromatous proliferation of hands and feet. | ||
Population: | |||
*Young adults | *Young adults. | ||
*20s | *Typically age (years) 20s and 30s.<ref name=pmid19057740/> | ||
==Location== | ==Location== | ||
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==Radiology== | ==Radiology== | ||
Marginated wide based bony growth projecting into the soft tissues<ref>http://radiopaedia.org/articles/bizarre-parosteal-osteochondromatous-proliferation</ref> | *Marginated wide based bony growth projecting into the soft tissues.<ref>http://radiopaedia.org/articles/bizarre-parosteal-osteochondromatous-proliferation</ref> | ||
==Gross== | ==Gross== | ||
*Nodule covered with glistening cartilage | *Nodule covered with glistening cartilage. | ||
==Microscopic== | ==Microscopic== | ||
Disorganized cellular cartilage with a blue tint and patchy ossification matures into disorganized bone. A proliferation of fibroblasts surrounds the lesion and occupies intertrabecular spaces. | Disorganized cellular cartilage with a blue tint and patchy ossification matures into disorganized bone. A proliferation of fibroblasts surrounds the lesion and occupies intertrabecular spaces. | ||
==Images== | DDx: | ||
Image | *Periosteal [[chondrosarcoma]]. | ||
Image | *Periosteal [[chondroma]]. | ||
*Low grade parosteal [[osteosarcoma]]. | |||
*[[Osteochondroma]]. | |||
===Images=== | |||
<gallery> | |||
Image:Bone BizzareParostealOsteochondromatousProliferation PA (2).JPG |Notice the disorganized blue tinted cartilage with partial ossification merging into mature bone. | |||
Image:Bone BizzareParostealOsteochondromatousProliferation PA.JPG |A loose proliferation of fibroblasts fills the spaces between the bony trabeculae. | |||
</gallery> | |||
*BPOP[http://www.webpathology.com/images/noimage.gif] | *BPOP[http://www.webpathology.com/images/noimage.gif] | ||
*BPOP[http://webpathology.com/images/noimage.gif] | *BPOP[http://webpathology.com/images/noimage.gif] | ||
*BPOP[http://www.webpathology.com/images/noimage.gif] | *BPOP[http://www.webpathology.com/images/noimage.gif] | ||
*BPOP[http://pathologyoutlines.com/wick/bizarre%20parosteal%20osteochondromatous%20proliferation%20(bpop-%20no.jpg] | *BPOP[http://pathologyoutlines.com/wick/bizarre%20parosteal%20osteochondromatous%20proliferation%20(bpop-%20no.jpg] | ||
==Diangostic categories== | ==Diangostic categories== | ||
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==Molecular== | ==Molecular== | ||
t(1:17)(q32;q21)<ref>{{Cite journal | last1 = Kuruvilla | first1 = S. | last2 = Marco | first2 = R. | last3 = Raymond | first3 = AK. | last4 = Al-Ibraheemi | first4 = A. | last5 = Tatevian | first5 = N. | title = BizarreParosteal Osteochondromatous Proliferation (Nora's lesion) with translocation t(1;17)(q32;q21): a case report and role of cytogenetic studies on diagnosis. | journal = Ann Clin Lab Sci | volume = 41 | issue = 3 | pages = 285-7 | month = | year = 2011 | doi = | PMID = 22075515 }} | t(1:17)(q32;q21)<ref>{{Cite journal | last1 = Kuruvilla | first1 = S. | last2 = Marco | first2 = R. | last3 = Raymond | first3 = AK. | last4 = Al-Ibraheemi | first4 = A. | last5 = Tatevian | first5 = N. | title = BizarreParosteal Osteochondromatous Proliferation (Nora's lesion) with translocation t(1;17)(q32;q21): a case report and role of cytogenetic studies on diagnosis. | journal = Ann Clin Lab Sci | volume = 41 | issue = 3 | pages = 285-7 | month = | year = 2011 | doi = | PMID = 22075515 }}</ref> | ||
</ref> | |||
==Sign out== | ==Sign out== | ||
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==References== | ==References== | ||
{{Reflist|1}} | {{Reflist|1}} | ||
[[Category:Diagnosis]] | |||