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Difference between revisions of "Peripheral nerve sheath tumours"
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Peripheral nerve sheath tumours (view source)
Revision as of 02:19, 7 January 2011
, 02:19, 7 January 2011→Schwannoma: subtypes
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===Microscopic=== | ===Microscopic=== | ||
Features:<ref name=pmid17893219>{{cite journal |author=Wippold FJ, Lubner M, Perrin RJ, Lämmle M, Perry A |title=Neuropathology for the neuroradiologist: Antoni A and Antoni B tissue patterns |journal=AJNR Am J Neuroradiol |volume=28 |issue=9 |pages=1633–8 |year=2007 |month=October |pmid=17893219 |doi=10.3174/ajnr.A0682 |url=http://www.ajnr.org/cgi/reprint/28/9/1633}}</ref> | Features:<ref name=pmid17893219>{{cite journal |author=Wippold FJ, Lubner M, Perrin RJ, Lämmle M, Perry A |title=Neuropathology for the neuroradiologist: Antoni A and Antoni B tissue patterns |journal=AJNR Am J Neuroradiol |volume=28 |issue=9 |pages=1633–8 |year=2007 |month=October |pmid=17893219 |doi=10.3174/ajnr.A0682 |url=http://www.ajnr.org/cgi/reprint/28/9/1633}}</ref> | ||
*Antoni | *Antoni A: | ||
**Cellular. | |||
**'Fibrillary, polar, elongated'. | |||
*Antoni B: | |||
**Pauci-cellular. | |||
**Loose microcystic tissue. | |||
*Verocay bodies - paucinuclear area surrounded by nuclei. | *Verocay bodies - paucinuclear area surrounded by nuclei. | ||
*In the GI tract: classically have a ''peripheral lymphoid cuff''.<ref name=pmid15728600>{{cite journal |author=Levy AD, Quiles AM, Miettinen M, Sobin LH |title=Gastrointestinal schwannomas: CT features with clinicopathologic correlation |journal=AJR Am J Roentgenol |volume=184 |issue=3 |pages=797–802 |year=2005 |month=March |pmid=15728600 |doi= |url=http://www.ajronline.org/cgi/content/full/184/3/797}}</ref> | *In the GI tract: classically have a ''peripheral lymphoid cuff''.<ref name=pmid15728600>{{cite journal |author=Levy AD, Quiles AM, Miettinen M, Sobin LH |title=Gastrointestinal schwannomas: CT features with clinicopathologic correlation |journal=AJR Am J Roentgenol |volume=184 |issue=3 |pages=797–802 |year=2005 |month=March |pmid=15728600 |doi= |url=http://www.ajronline.org/cgi/content/full/184/3/797}}</ref> | ||
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Notes: | Notes: | ||
*Tumour does ''not'' smear well.<ref>MUN. 24 November 2010.</ref> | *Tumour does ''not'' smear well.<ref>MUN. 24 November 2010.</ref> | ||
*Antoni A: may look somewhat like scattered matchsticks. | |||
Micrographs: | Micrographs: | ||
*[http://www.pathguy.com/~lulo/lulo0003.htm Antoni A (pathguy.com)]. | *[http://www.pathguy.com/~lulo/lulo0003.htm Antoni A (pathguy.com)]. | ||
*[http://www.ajnr.org/cgi/content/full/28/9/1633/F8 Antoni A & Antoni B side-by-side (ajnr.org)]. | *[http://www.ajnr.org/cgi/content/full/28/9/1633/F8 Antoni A & Antoni B side-by-side (ajnr.org)]. | ||
====Subtypes==== | |||
There are four:<ref name=pmid12792904>{{cite journal |author=Kurtkaya-Yapicier O, Scheithauer B, Woodruff JM |title=The pathobiologic spectrum of Schwannomas |journal=Histol. Histopathol. |volume=18 |issue=3 |pages=925–34 |year=2003 |month=July |pmid=12792904 |doi= |url=}}</ref> | |||
#Conventional. | |||
#*Most common. | |||
#Cellular. | |||
#*May mimic [[MPNST]]. | |||
#Plexiform. | |||
#*May mimic [[MPNST]] if cellular - esp. in childhood. | |||
#Melanotic. | |||
#*May be confused with [[melanoma]]. | |||
#*Psammomatous form associated with a heritable disorder (Carney complex). | |||
Notes: | |||
*Carney complex:<ref name=pmid12792904/> | |||
**Cutaneous lentigines. | |||
**Myxomas (skin (subcutaneous), subcutanous, [[Cardiac tumours#Atrial myxoma|heart]]). | |||
**Endocrine neoplasms. | |||
==Traumatic neuroma== | ==Traumatic neuroma== | ||