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Difference between revisions of "Metaphyseal fibrous defect"
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Metaphyseal fibrous defect (view source)
Revision as of 08:36, 14 October 2014
, 08:36, 14 October 2014no edit summary
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| Caption = | | Caption = | ||
| Synonyms = Nonossifying fibroma | | Synonyms = Nonossifying fibroma | ||
| Micro = | | Micro = | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
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| Site = | | Site = | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = Incidental | | Clinicalhx = Incidental radiograhic finding | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = | | Prevalence = | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = Lucent defect | | Rads = Lucent defect | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = | ||
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==Synonyms== | ==Synonyms== | ||
*Nonossifying fibroma | *Nonossifying fibroma (larger but otherwise identical) | ||
*Fibrous cortical defect | *Fibrous cortical defect | ||
*Fibrous metaphyseal defect | *Fibrous metaphyseal defect | ||
*Fibroxanthoma of bone | |||
==Site== | ==Site== | ||
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*Metaphysis | *Metaphysis | ||
*Long bones | *Long bones | ||
*Eccentric location | |||
==Gross== | ==Gross== | ||
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==Microscopic== | ==Microscopic== | ||
Spindle cells without cytologic atypia are arranged in a storiform pattern with scattered chronic inflammatory cells and benign giant cells. Foam cells and hemosiderin deposition are present. Mitoses are seen but cytologic atypia is absent. | Spindle cells without cytologic atypia are arranged in a storiform pattern with scattered chronic inflammatory cells and benign giant cells. Foam cells and hemosiderin deposition are present. Mitoses are seen but cytologic atypia is absent. | ||
==Differential Diagnosis== | |||
*Giant cell tumor of bone (epiphyseal location, occurs in adults) | |||
==Relevant Diagnostic Groups== | |||
*FOG MACHINES - acronym for radiographically lytic bone lesions <ref {{http://radiopaedia.org/articles/lytic-bone-lesion-mnemonic}} /ref> | |||
*Giant cell lesions of bone. | |||
*Spindle cell lesions of bone. | |||
==Images== | |||
*http://njms2.umdnj.edu/tutorweb/casegifs/nofhe1.jpg | |||
*http://njms2.umdnj.edu/tutorweb/casegifs/nofhe2.jpg | |||
*http://njms2.umdnj.edu/tutorweb/casegifs/nofhe1.jpg | |||
*http://pathologyoutlines.com/wick/non-ossifying%20fibroma%20(metaphyseal%20fibrous%20defect)%20micro.jpg | |||
==Stains== | ==Stains== | ||
Not relevant. | Not relevant. | ||
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==Syndromes== | ==Syndromes== | ||
Jaffe-Campanacci syndrome | Jaffe-Campanacci syndrome <ref{{http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome}}/ref> | ||
==Clinical history== | ==Clinical history== | ||
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==Radiographic findings== | ==Radiographic findings== | ||
Sharply demarcated, lucent, loculated, meta-diaphyseal lesion surrounded by a rim of sclerotic bone | Sharply demarcated, lucent, loculated, meta-diaphyseal lesion surrounded by a rim of sclerotic bone | ||
==Sign out== | ==Sign out== | ||
BONE; CURETTAGE: METAPHYSEAL FIBROUS DEFECT. | BONE; CURETTAGE: METAPHYSEAL FIBROUS DEFECT. | ||
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*http://njms2.umdnj.edu/tutorweb/case8.htm | *http://njms2.umdnj.edu/tutorweb/case8.htm | ||
*http://www.pathologyoutlines.com/topic/bonemetaphysealfibrousdefect.html | *http://www.pathologyoutlines.com/topic/bonemetaphysealfibrousdefect.html | ||
*http://radiopaedia.org/articles/fibrous-cortical-defect | |||
*http://radiopaedia.org/articles/non-ossifying-fibroma-1 | |||
==References== | ==References== | ||