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Line 102: | Line 102: | ||
**β-catenin accumulates in the nucleus. | **β-catenin accumulates in the nucleus. | ||
*Loss of function mutation in the APC gene. | *Loss of function mutation in the APC gene. | ||
**~15% of sporadic desmoids. | **~15% of sporadic desmoids.<ref name=pmid23020601/> | ||
** All familial adenomatous polyposis associated desmoids. | ** All familial adenomatous polyposis associated desmoids. | ||
**APC product unavailable to interact with β-catenin.<ref>URL: [http://ghr.nlm.nih.gov/condition/desmoid-tumor http://ghr.nlm.nih.gov/condition/desmoid-tumor]. Accessed on: 4 October 2014.</ref> | **APC product unavailable to interact with β-catenin.<ref>URL: [http://ghr.nlm.nih.gov/condition/desmoid-tumor http://ghr.nlm.nih.gov/condition/desmoid-tumor]. Accessed on: 4 October 2014.</ref> |
edits