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Difference between revisions of "Papillary cystadenoma of the epididymis"
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Papillary cystadenoma of the epididymis (view source)
Revision as of 18:16, 31 May 2016
, 18:16, 31 May 2016no edit summary
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Papillary_cystadenoma_of_epididymis_--_high_mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Papillary cystadenoma of epididymis. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = cystic spaces with papillae lined by clear cells with moderate cytoplasm | | Micro = cystic spaces with papillae lined by clear cells with moderate cytoplasm | ||
| Line 13: | Line 13: | ||
| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = | | Gross = solid and/or cystic mass, well-circumscribed | ||
| Grossing = | | Grossing = | ||
| Site = [[epididymis]] | | Site = [[epididymis]] | ||
| Line 27: | Line 27: | ||
| Prognosis = benign | | Prognosis = benign | ||
| Other = | | Other = | ||
| ClinDDx = testicular masses | | ClinDDx = testicular masses - esp. [[germ cell tumours]], [[paratesticular lesion]]s | ||
| Tx = excision | | Tx = excision | ||
}} | }} | ||
'''Papillary cystadenoma of the epididymis''' is a rare benign epithelial tumour of the epididymis.<ref name=pmid23708309>{{Cite journal | last1 = Toutziaris | first1 = C. | last2 = Kampantais | first2 = S. | last3 = Perdikis | first3 = I. | last4 = Gourvas | first4 = V. | last5 = Laskaridis | first5 = L. | last6 = Gkagkalidis | first6 = K. | last7 = Lakis | first7 = S. | last8 = Ioannidis | first8 = S. | title = Papillary cystadenoma of epididymis: Is there a need for further investigation in unilateral cases? | journal = Int J Surg Case Rep | volume = 4 | issue = 7 | pages = 616-8 | month = | year = 2013 | doi = 10.1016/j.ijscr.2013.03.038 | PMID = 23708309 }}</ref> | '''Papillary cystadenoma of the epididymis''' is a rare benign epithelial tumour of the [[epididymis]].<ref name=pmid23708309>{{Cite journal | last1 = Toutziaris | first1 = C. | last2 = Kampantais | first2 = S. | last3 = Perdikis | first3 = I. | last4 = Gourvas | first4 = V. | last5 = Laskaridis | first5 = L. | last6 = Gkagkalidis | first6 = K. | last7 = Lakis | first7 = S. | last8 = Ioannidis | first8 = S. | title = Papillary cystadenoma of epididymis: Is there a need for further investigation in unilateral cases? | journal = Int J Surg Case Rep | volume = 4 | issue = 7 | pages = 616-8 | month = | year = 2013 | doi = 10.1016/j.ijscr.2013.03.038 | PMID = 23708309 }}</ref> | ||
''Papillary cystadenoma'' redirects here. | |||
==General== | ==General== | ||
| Line 41: | Line 43: | ||
Clinical:<ref name=pmid20367315/> | Clinical:<ref name=pmid20367315/> | ||
*Slow growing scrotal mass or incidental finding. | *Slow growing scrotal mass or incidental finding. | ||
==Gross== | |||
*Well-circumscribed mass. | |||
*Solid and/or cystic. | |||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid20367315/> | Features:<ref name=pmid20367315/> | ||
| Line 55: | Line 61: | ||
===Images=== | ===Images=== | ||
====Case==== | |||
<gallery> | |||
Image: Papillary cystadenoma of epididymis -- very low mag.jpg | PCE - very low mag. | |||
Image: Papillary cystadenoma of epididymis -- low mag.jpg | PCE - low mag. | |||
Image: Papillary cystadenoma of epididymis - alt -- low mag.jpg | PCE - low mag. | |||
Image: Papillary cystadenoma of epididymis -- intermed mag.jpg | PCE - intermed. mag. | |||
Image: Papillary cystadenoma of epididymis -- high mag.jpg | PCE - high mag. | |||
Image: Papillary cystadenoma of epididymis -- very low high.jpg | PCE - very high mag. | |||
</gallery> | |||
====www==== | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679418/figure/fig0020/ PC (nih.gov)].<ref name=pmid23708309/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679418/figure/fig0020/ PC (nih.gov)].<ref name=pmid23708309/> | ||
*[http://www.archivesofpathology.org/action/showFullPopup?id=i1543-2165-134-4-630-f01&doi=10.1043%2F1543-2165-134.4.630 PC (archivesofpathology.org)].<ref name=pmid20367315>{{Cite journal | last1 = Odrzywolski | first1 = KJ. | last2 = Mukhopadhyay | first2 = S. | title = Papillary cystadenoma of the epididymis. | journal = Arch Pathol Lab Med | volume = 134 | issue = 4 | pages = 630-3 | month = Apr | year = 2010 | doi = 10.1043/1543-2165-134.4.630 | PMID = 20367315 }}</ref> | *[http://www.archivesofpathology.org/action/showFullPopup?id=i1543-2165-134-4-630-f01&doi=10.1043%2F1543-2165-134.4.630 PC (archivesofpathology.org)].<ref name=pmid20367315>{{Cite journal | last1 = Odrzywolski | first1 = KJ. | last2 = Mukhopadhyay | first2 = S. | title = Papillary cystadenoma of the epididymis. | journal = Arch Pathol Lab Med | volume = 134 | issue = 4 | pages = 630-3 | month = Apr | year = 2010 | doi = 10.1043/1543-2165-134.4.630 | PMID = 20367315 }}</ref> | ||
| Line 63: | Line 80: | ||
*EMA +ve (9 of 9 cases). | *EMA +ve (9 of 9 cases). | ||
*CK7 +v3 (3 of 3 cases). | *CK7 +v3 (3 of 3 cases). | ||
*PAX8 +ve (6 of 7 cases<ref name=pmid24441657>{{Cite journal | last1 = Cox | first1 = R. | last2 = Vang | first2 = R. | last3 = Epstein | first3 = JI. | title = Papillary cystadenoma of the epididymis and broad ligament: morphologic and immunohistochemical overlap with clear cell papillary renal cell carcinoma. | journal = Am J Surg Pathol | volume = 38 | issue = 5 | pages = 713-8 | month = May | year = 2014 | doi = 10.1097/PAS.0000000000000152 | PMID = 24441657 }}</ref>) | |||
Others:<ref name=pmid20367315/> | Others:<ref name=pmid20367315/> | ||
*Vimentin +ve/-ve (3 of 6 cases +ve). | *Vimentin +ve/-ve (3 of 6 cases +ve). | ||
*CD10 -ve (0 of 5 cases | *CD10 -ve (0 +ve of 5 cases). | ||
*CK20 -ve (0 of 4 cases | *CK20 -ve (0 +ve of 4 cases). | ||
*S100 -ve (1 of 4 cases +ve). | *S100 -ve (1 +ve of 4 cases). | ||
*RCC -ve (0 +ve of 7 cases<ref name=pmid24441657/>). | |||
*AMACR -ve (2 weakly +ve of 7 cases<ref name=pmid24441657/>). | |||
Note: | |||
*''Papillary cystadenoma of the epithymis'' has an immunoprofile that is nearly identical to [[clear cell papillary renal cell carcinoma]].<ref name=pmid24441657/> | |||
==Sign out== | |||
<pre> | |||
Right Epididymis, Mass, Excision: | |||
- Papillary cystadenoma of the epididymis, see comment | |||
Comment: | |||
The tumour stains as follows: | |||
POSITIVE: AE1/AE3, vimentin | |||
NEGATIVE: CD10, calretinin, CD68, S100, OCT3/4 | |||
Papillary cystadenoma of the epididymis is a benign uncommon | |||
tumour. Approximately 60 cases are reported in the literature. | |||
It is associated with von Hippel-Lindau disease in approximately | |||
1/3 of cases. | |||
</pre> | |||
==See also== | ==See also== | ||