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Difference between revisions of "Lung metastasis"
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==IHC== | ==IHC== | ||
*TTF-1 -ve | *TTF-1 -ve/+ve. | ||
*CK20 +ve/-ve | **Negative suggestive of metastasis... unless it is [[squamous carcinoma]]. | ||
*GATA3 +ve/-ve | *CK20 +ve/-ve. | ||
*CK7 -ve/+ve | **Positive in colorectal carcinoma - very useful. | ||
**Negative in lung primaries. | |||
*GATA3 +ve/-ve. | |||
**Usu. +ve in [[urothelial carcinoma]]. | |||
**Negative in lung primaries.<ref>{{Cite journal | last1 = Chang | first1 = A. | last2 = Amin | first2 = A. | last3 = Gabrielson | first3 = E. | last4 = Illei | first4 = P. | last5 = Roden | first5 = RB. | last6 = Sharma | first6 = R. | last7 = Epstein | first7 = JI. | title = Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung. | journal = Am J Surg Pathol | volume = 36 | issue = 10 | pages = 1472-6 | month = Oct | year = 2012 | doi = 10.1097/PAS.0b013e318260cde7 | PMID = 22982890 }}</ref> | |||
*CK7 -ve/+ve. | |||
**Positive in lung adenocarcinoma and small carcinoma of the lung. | |||
**Positive in a number of other tumours - breast, upper GI tract, thyroid, mesothelioma, [[salivary gland]]. | |||
**Negative in poorly differentiated carcinoma of the lung and squamous carcinoma of the lung. | |||
==See also== | ==See also== | ||