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| | -small vessel <br> -medium vessel <br> -large vessel | | | -small vessel <br> -medium vessel <br> -large vessel |
| | -[[leukocytoclastic vasculitis]]<br>-[[PAN]]<br>-[[giant cell arteritis]] | | | -[[leukocytoclastic vasculitis]]<br>-[[PAN]]<br>-[[giant cell arteritis]] |
| | [[Image:Churg-Strauss_syndrome_-_high_mag.jpg |thumb|150px|[[Churg-Strauss syndrome|CCS]] (WC)]] | | | [[Image:Churg-Strauss_syndrome_-_high_mag.jpg |thumb|150px|[[Eosinophilic granulomatosis with polyangiitis|EGPA]] (WC)]] |
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| | [[Dermatitides_with_perivascular_inflammation|Perivascular]] | | | [[Dermatitides_with_perivascular_inflammation|Perivascular]] |
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| Common locations:<ref name=Ref_PCPBoD8_603>{{Ref PCPBoD8|603}}</ref> | | Common locations:<ref name=Ref_PCPBoD8_603>{{Ref PCPBoD8|603}}</ref> |
| *Knees, elbows, scalp, glands [[penis]]. | | *Knees, elbows, scalp, glans [[penis]]. |
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| ===Microscopic=== | | ===Microscopic=== |
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| DDx ''rips'': | | DDx ''rips'': |
| *Rheumatoid neutrophilic dermatitis. | | *Rheumatoid neutrophilic dermatitis. |
| *Bowel-associated dermatosis-arthritis syndrome. | | *[[Bowel-associated dermatosis-arthritis syndrome]] (BADAS). |
| *[[Pyoderma gangrenosum]]. | | *[[Pyoderma gangrenosum]]. |
| *Sweet syndrome. | | *Sweet syndrome. |
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| ==Pyoderma gangrenosum== | | ==Pyoderma gangrenosum== |
| ===General===
| | {{Main|Pyoderma gangrenosum}} |
| *May be seen in [[IBD]] (UC and CD) - approximately 30% of cases.<ref name=pmid16858047/>
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| Clinical
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| *''[[Pathergy]]'' = minor trauma (to the skin) results in a non-healing lesion.<ref name=pmid22202507>{{Cite journal | last1 = Wong | first1 = WW. | last2 = Machado | first2 = GR. | last3 = Hill | first3 = ME. | title = Pyoderma gangrenosum: the great pretender and a challenging diagnosis. | journal = J Cutan Med Surg | volume = 15 | issue = 6 | pages = 322-8 | month = | year = | doi = | PMID = 22202507 }}</ref>
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| ===Gross===
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| *Skin ulceration - classically on the legs.<ref name=pmid16858047>{{Cite journal | last1 = Brooklyn | first1 = T. | last2 = Dunnill | first2 = G. | last3 = Probert | first3 = C. | title = Diagnosis and treatment of pyoderma gangrenosum. | journal = BMJ | volume = 333 | issue = 7560 | pages = 181-4 | month = Jul | year = 2006 | doi = 10.1136/bmj.333.7560.181 | PMID = 16858047 | PMC = 1513476 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513476/?tool=pubmed }}</ref>
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| ===Microscopic===
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| Features:<ref name=pmid16858047/>
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| *Early: lymphocytes cells only in the dermis - often perivascular & vascular.
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| **+/-Fibrinoid necrosis of vessels at edge of lesion.
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| *Late: abscess formation ([[neutrophil]]s).
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| DDx:
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| *[[Vasculitis]].
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| *[[Sweet syndrome]].
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| Image:
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| *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513476/figure/fig5/ Pyoderma gangrenosum (nih.gov)].
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| ==Necrobiotic xanthogranuloma== | | ==Necrobiotic xanthogranuloma== |
| *Abbreviated ''NXG''. | | *Abbreviated ''NXG''. |
| ===General===
| | {{Main|Necrobiotic xanthogranuloma}} |
| *Usually elderly.<ref name=Ref_Derm629>{{Ref Derm|629}}</ref>
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| ===Gross===
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| Features:
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| *Periorbital - classic location.<ref name=pmid17544963>{{Cite journal | last1 = Fernández-Herrera | first1 = J. | last2 = Pedraz | first2 = J. | title = Necrobiotic xanthogranuloma. | journal = Semin Cutan Med Surg | volume = 26 | issue = 2 | pages = 108-13 | month = Jun | year = 2007 | doi = 10.1016/j.sder.2007.02.008 | PMID = 17544963 }}</ref>
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| ===Microscopic===
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| Features:<ref name=Ref_Derm629>{{Ref Derm|629}}</ref>
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| *"Necrobiotic granuloma":
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| **Palisading granuloma with a core collagen-like material.
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| *+/-Cholesterol clefts - common.
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| *+/-[[Touton giant cell]]s.
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| *+/-Atypical foreign body-type giant cells +/- asteroid bodies.
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| DDx:
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| *[[Granuloma annulare]].
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| *[[Necrobiosis lipoidica]] - has plasma cells.
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| *Granuloma-forming infections - positive stains for microorganisms.
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| Image:
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| *[http://commons.wikimedia.org/wiki/File:Asteroid_bodies_high_mag_cropped.jpg Asteroid body (WC)].
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| =DDx for pattern= | | =DDx for pattern= |
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| *'''L'''upus erythematosus. | | *'''L'''upus erythematosus. |
| *'''L'''ymphocytic infiltrate of Jessner / tumid lupus erythematosus. | | *'''L'''ymphocytic infiltrate of Jessner / tumid lupus erythematosus. |
| *Polymorphous '''l'''ight eruption. | | *[[polymorphous light eruption|Polymorphous '''l'''ight eruption]]. |
| *'''L'''yme disease. | | *'''L'''yme disease. |
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| ===Neutrophils=== | | ===Neutrophils=== |
| DDx:<ref name=pmid18418089/> | | DDx:<ref name=pmid18418089/> |
| *Cellulitis. | | *[[Cellulitis]]. |
| *Neutrophilic eccrine hidradenitis (idiopathic palmar-plantar hidradenitis) | | *Neutrophilic eccrine hidradenitis (idiopathic palmar-plantar hidradenitis) |
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